Balanced interhemispheric cortical activity is required for correct targeting of the corpus callosum

Rodrigo Suárez, Laura R. Fenlon, Roger Marek, Lilach Avitan, Pankaj Sah, Geoffrey J. Goodhill, Linda J. Richards

Research output: Contribution to journalArticlepeer-review

53 Scopus citations

Abstract

Bilateral integration of sensory and associative brain processing is achieved by precise connections between homologous regions in the two hemispheres via the corpus callosum. These connections form postnatally, and unilateral deprivation of sensory or spontaneous cortical activity during a critical period severely disrupts callosal wiring. However, little is known about how this early activity affects precise circuit formation. Here, using in utero electroporation of reporter genes, optogenetic constructs, and direct disruption of activity in callosal neurons combined with whisker ablations, we show that balanced interhemispheric activity, and not simply intact cortical activity in either hemisphere, is required for functional callosal targeting. Moreover, bilateral ablation of whiskers in symmetric or asymmetric configurations shows that spatially symmetric interhemispheric activity is required for appropriate callosal targeting. Our findings reveal a principle governing axon targeting, where spatially balanced activity between regions is required to establish their appropriate connectivity

Original languageEnglish
Pages (from-to)1289-1298
Number of pages10
JournalNeuron
Volume82
Issue number6
DOIs
StatePublished - Jun 18 2014

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