Bad Ac-etylated Tau

Jane C. Hettinger, John R. Cirrito

Research output: Contribution to journalShort surveypeer-review

4 Scopus citations

Abstract

By using a tau construct with two mimicked acetylation sites as identified in AD brains, Tracy et al. (2016) found that acetylated tau promotes synaptic dysfunction through disruption of postsynaptic KIBRA signaling pathways, actin dynamics, and AMPA receptor trafficking. By using a tau construct with two mimicked acetylation sites as identified in AD brains, Tracy et al. found that acetylated tau promotes synaptic dysfunction through disruption of postsynaptic KIBRA signaling pathways, actin dynamics, and AMPA receptor trafficking.

Original languageEnglish
Pages (from-to)205-206
Number of pages2
JournalNeuron
Volume90
Issue number2
DOIs
StatePublished - Apr 20 2016

Keywords

  • Acetylation
  • Alzheimer's disease
  • KIBRA
  • Post-translational modification
  • Tau
  • Tauopathy

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