TY - JOUR
T1 - Bacterial type IV secretion
T2 - Conjugation systems adapted to deliver effector molecules to host cells
AU - Christie, Peter J.
AU - Vogel, Joseph P.
N1 - Funding Information:
We express special thanks to scientists working on conjugation systems for laying a foundation of knowledge about these newly termed type IV systems. We apologize for any omissions of citations to original data cited herein owing to space limitations; the original references can be found in the reviews cited. Additional information on the type IV systems can be found in the accompanying review by E-M. Lai and C.I. Kado. Work in the P.J.C. laboratory is funded by the NIH (GM48746).
PY - 2000/8/1
Y1 - 2000/8/1
N2 - Several bacterial pathogens utilize conjugation machines to export effector molecules during infection. Such systems are members of the type IV or 'adapted conjugation' secretion family. The prototypical type IV system is the Agrobacterium tumefaciens T-DNA transfer machine, which delivers oncogenic nucleoprotein particles to plant cells. Other pathogens, including Bordetella pertussis, Legionella pneumophila, Brucella spp. and Helicobacter pylori, use type IV machines to export effector proteins to the extracellular milieu or the mammalian cell cytosol.
AB - Several bacterial pathogens utilize conjugation machines to export effector molecules during infection. Such systems are members of the type IV or 'adapted conjugation' secretion family. The prototypical type IV system is the Agrobacterium tumefaciens T-DNA transfer machine, which delivers oncogenic nucleoprotein particles to plant cells. Other pathogens, including Bordetella pertussis, Legionella pneumophila, Brucella spp. and Helicobacter pylori, use type IV machines to export effector proteins to the extracellular milieu or the mammalian cell cytosol.
UR - http://www.scopus.com/inward/record.url?scp=0034255091&partnerID=8YFLogxK
U2 - 10.1016/S0966-842X(00)01792-3
DO - 10.1016/S0966-842X(00)01792-3
M3 - Review article
C2 - 10920394
AN - SCOPUS:0034255091
SN - 0966-842X
VL - 8
SP - 354
EP - 360
JO - Trends in Microbiology
JF - Trends in Microbiology
IS - 8
ER -