Bacterial pili: Molecular mechanisms of pathogenesis

Frederic G. Sauer; Matthew A. Mulvey; Joel D. Schilling; Juan J. Martinez; Scott J. Hultgren

doi:10.1016/S1369-5274(99)00053-3

Bacterial pili: Molecular mechanisms of pathogenesis

Frederic G. Sauer
, Matthew A. Mulvey
, Joel D. Schilling
, Juan J. Martinez
, Scott J. Hultgren

Research output: Contribution to journal › Review article › peer-review

182 Scopus citations

Abstract

Gram-negative bacteria produce a diverse array of pili that mediate microbe-microbe and host-pathogen interactions important in the development of disease. The structural and functional characterization of these organelles, particularly their role in triggering signals in both the bacterium and the host upon attachment, has begun to reveal the molecular mechanisms of bacterial diseases.

Original language	English
Pages (from-to)	65-72
Number of pages	8
Journal	Current Opinion in Microbiology
Volume	3
Issue number	1
DOIs	https://doi.org/10.1016/S1369-5274(99)00053-3
State	Published - Feb 1 2000

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title = "Bacterial pili: Molecular mechanisms of pathogenesis",

abstract = "Gram-negative bacteria produce a diverse array of pili that mediate microbe-microbe and host-pathogen interactions important in the development of disease. The structural and functional characterization of these organelles, particularly their role in triggering signals in both the bacterium and the host upon attachment, has begun to reveal the molecular mechanisms of bacterial diseases.",

author = "Sauer, \{Frederic G.\} and Mulvey, \{Matthew A.\} and Schilling, \{Joel D.\} and Martinez, \{Juan J.\} and Hultgren, \{Scott J.\}",

note = "Funding Information: SJ Hultgren is supported by National Institutes of Health (NIH) grants RO1DK51406 and RO1AI29549 and MA Malvey by NIH fellowship AI09787. FG Sauer was supported by a National Science Foundation Predoctoral Fellowship. JD Schilling is a member of the Medical Science Training Program. ",

year = "2000",

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doi = "10.1016/S1369-5274(99)00053-3",

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TY - JOUR

T1 - Bacterial pili

T2 - Molecular mechanisms of pathogenesis

AU - Sauer, Frederic G.

AU - Mulvey, Matthew A.

AU - Schilling, Joel D.

AU - Martinez, Juan J.

AU - Hultgren, Scott J.

N1 - Funding Information: SJ Hultgren is supported by National Institutes of Health (NIH) grants RO1DK51406 and RO1AI29549 and MA Malvey by NIH fellowship AI09787. FG Sauer was supported by a National Science Foundation Predoctoral Fellowship. JD Schilling is a member of the Medical Science Training Program.

PY - 2000/2/1

Y1 - 2000/2/1

N2 - Gram-negative bacteria produce a diverse array of pili that mediate microbe-microbe and host-pathogen interactions important in the development of disease. The structural and functional characterization of these organelles, particularly their role in triggering signals in both the bacterium and the host upon attachment, has begun to reveal the molecular mechanisms of bacterial diseases.

AB - Gram-negative bacteria produce a diverse array of pili that mediate microbe-microbe and host-pathogen interactions important in the development of disease. The structural and functional characterization of these organelles, particularly their role in triggering signals in both the bacterium and the host upon attachment, has begun to reveal the molecular mechanisms of bacterial diseases.

UR - https://www.scopus.com/pages/publications/0033972472

U2 - 10.1016/S1369-5274(99)00053-3

DO - 10.1016/S1369-5274(99)00053-3

M3 - Review article

C2 - 10679419

AN - SCOPUS:0033972472

SN - 1369-5274

VL - 3

SP - 65

EP - 72

JO - Current Opinion in Microbiology

JF - Current Opinion in Microbiology

IS - 1

ER -

Bacterial pili: Molecular mechanisms of pathogenesis

Abstract

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