Bacterial pili: Molecular mechanisms of pathogenesis

Frederic G. Sauer, Matthew A. Mulvey, Joel D. Schilling, Juan J. Martinez, Scott J. Hultgren

Research output: Contribution to journalReview articlepeer-review

152 Scopus citations

Abstract

Gram-negative bacteria produce a diverse array of pili that mediate microbe-microbe and host-pathogen interactions important in the development of disease. The structural and functional characterization of these organelles, particularly their role in triggering signals in both the bacterium and the host upon attachment, has begun to reveal the molecular mechanisms of bacterial diseases.

Original languageEnglish
Pages (from-to)65-72
Number of pages8
JournalCurrent Opinion in Microbiology
Volume3
Issue number1
DOIs
StatePublished - Feb 1 2000

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