TY - JOUR
T1 - Bacterial Outer Membrane Vesicles
T2 - From Discovery to Applications
AU - Sartorio, Mariana G.
AU - Pardue, Evan J.
AU - Feldman, Mario F.
AU - Haurat, M. Florencia
N1 - Funding Information:
We thank Juvenal Lopez for critical reading of the manuscript. This work was supported by National Institute of Allergy and Infectious Diseases grant R21AI151873, awarded to M.F.F, and a National Institutes of Health training program in “Cellular and Molecular Biology” awarded to E.J.P.
Publisher Copyright:
© 2021 Annual Reviews Inc.. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Secretion of cellular components across the plasma membrane is an essential process that enables organisms to interact with their environments. Production of extracellular vesicles in bacteria is a well-documented but poorly understood process. Outer membrane vesicles (OMVs) are produced in gram-negative bacteria by blebbing of the outer membrane. In addition to their roles in pathogenesis, cell-to-cell communication, and stress responses, OMVs play important roles in immunomodulation and the establishment and balance of the gut microbiota. In this review, we discuss the multiple roles of OMVs and the current knowledge of OMV biogenesis. We also discuss the growing and promising biotechnological applications of OMV.
AB - Secretion of cellular components across the plasma membrane is an essential process that enables organisms to interact with their environments. Production of extracellular vesicles in bacteria is a well-documented but poorly understood process. Outer membrane vesicles (OMVs) are produced in gram-negative bacteria by blebbing of the outer membrane. In addition to their roles in pathogenesis, cell-to-cell communication, and stress responses, OMVs play important roles in immunomodulation and the establishment and balance of the gut microbiota. In this review, we discuss the multiple roles of OMVs and the current knowledge of OMV biogenesis. We also discuss the growing and promising biotechnological applications of OMV.
KW - OMV
KW - commensalism
KW - outer membrane vesicle
KW - pathogenesis
KW - secretion system
KW - vaccines
UR - http://www.scopus.com/inward/record.url?scp=85117124457&partnerID=8YFLogxK
U2 - 10.1146/annurev-micro-052821-031444
DO - 10.1146/annurev-micro-052821-031444
M3 - Review article
C2 - 34351789
AN - SCOPUS:85117124457
SN - 0066-4227
VL - 75
SP - 609
EP - 630
JO - Annual review of microbiology
JF - Annual review of microbiology
ER -