TY - JOUR
T1 - Bacterial metabolic heterogeneity
T2 - origins and applications in engineering and infectious disease
AU - Evans, Trent D.
AU - Zhang, Fuzhong
N1 - Funding Information:
This work was supported by the National Institute of General Medical Sciences of the National Institutes of Health under Award Number R35GM133797. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health.
Publisher Copyright:
© 2020 The Author(s)
PY - 2020/8
Y1 - 2020/8
N2 - Bacteria within an isoclonal population display significant heterogeneity in metabolism, even under tightly controlled environmental conditions. Metabolic heterogeneity enables influential functions not possible or measurable at the ensemble scale. Several molecular and cellular mechanisms are likely to give rise to metabolic heterogeneity including molecular noise in metabolic enzyme expression, positive feedback loops, and asymmetric partitioning of cellular components during cell division. Dissection of the mechanistic origins of metabolic heterogeneity has been enabled by recent developments in single-cell analytical tools. Finally, we provide a discussion of recent studies examining the importance of metabolic heterogeneity in applied settings such as infectious disease and metabolic engineering.
AB - Bacteria within an isoclonal population display significant heterogeneity in metabolism, even under tightly controlled environmental conditions. Metabolic heterogeneity enables influential functions not possible or measurable at the ensemble scale. Several molecular and cellular mechanisms are likely to give rise to metabolic heterogeneity including molecular noise in metabolic enzyme expression, positive feedback loops, and asymmetric partitioning of cellular components during cell division. Dissection of the mechanistic origins of metabolic heterogeneity has been enabled by recent developments in single-cell analytical tools. Finally, we provide a discussion of recent studies examining the importance of metabolic heterogeneity in applied settings such as infectious disease and metabolic engineering.
UR - http://www.scopus.com/inward/record.url?scp=85086525453&partnerID=8YFLogxK
U2 - 10.1016/j.copbio.2020.04.007
DO - 10.1016/j.copbio.2020.04.007
M3 - Review article
C2 - 32574927
AN - SCOPUS:85086525453
SN - 0958-1669
VL - 64
SP - 183
EP - 189
JO - Current Opinion in Biotechnology
JF - Current Opinion in Biotechnology
ER -