TY - JOUR
T1 - Bacterial Cell Size
T2 - Multifactorial and Multifaceted
AU - Westfall, Corey S.
AU - Levin, Petra Anne
N1 - Funding Information:
We are grateful to members of the Levin laboratory past and present for 10 years of engaging and productive discussion on the biology and philosophy of bacterial cell size control. The multifaceted nature of cell size has required us to repeatedly venture into new and unfamiliar areas of inquiry. We are thus indebted to our many colleagues and friends who have generously provided reagents and materials and invaluable expertise to facilitate our research. Finally, we dedicate this review to Moselio (Elio) Schaechter for his pioneering work in bacterial physiology that set the stage for subsequent studies of bacterial cell size, for setting a high bar as a scientist and colleague, and for continuing to inspire others through his writing and his infectious appreciation for microbes in all their glory. This work was supported by National Institutes of Health grants GM64671 to P.A.L. C.S.W. was supported by an Arnold O. Beckman Postdoctoral Fellowship.
Publisher Copyright:
Copyright © 2017 by Annual Reviews. All rights reserved.
PY - 2017/9/8
Y1 - 2017/9/8
N2 - How cells establish, maintain, and modulate size has always been an area of great interest and fascination. Until recently, technical limitations curtailed our ability to understand the molecular basis of bacterial cell size control. In the past decade, advances in microfluidics, imaging, and high-throughput single-cell analysis, however, have led to a flurry of work revealing size to be a highly complex trait involving the integration of three core aspects of bacterial physiology: metabolism, growth, and cell cycle progression.
AB - How cells establish, maintain, and modulate size has always been an area of great interest and fascination. Until recently, technical limitations curtailed our ability to understand the molecular basis of bacterial cell size control. In the past decade, advances in microfluidics, imaging, and high-throughput single-cell analysis, however, have led to a flurry of work revealing size to be a highly complex trait involving the integration of three core aspects of bacterial physiology: metabolism, growth, and cell cycle progression.
KW - Cell cycle
KW - Cell size
KW - Homeostatic control
KW - Sizer
KW - Timer
UR - http://www.scopus.com/inward/record.url?scp=85029292440&partnerID=8YFLogxK
U2 - 10.1146/annurev-micro-090816-093803
DO - 10.1146/annurev-micro-090816-093803
M3 - Article
C2 - 28886685
AN - SCOPUS:85029292440
SN - 0066-4227
VL - 71
SP - 499
EP - 517
JO - Annual review of microbiology
JF - Annual review of microbiology
ER -