Bacterial and mammalian HMG-CoA reductases: Related enzymes with distinct architectures

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Abstract

The committed step in the biosynthesis of isoprenoids is catalyzed by HMG-CoA reductase. Recently determined structures of the distantly related bacterial and mammalian HMG-CoA reductases have revealed two distinct classes of the protein with differently formed active sites and oligomeric states. An appreciation of the remarkable differences in the active site architecture may ultimately lead to the development of novel antibacterial agents.

Original languageEnglish
Pages (from-to)746-751
Number of pages6
JournalCurrent Opinion in Structural Biology
Volume11
Issue number6
DOIs
StatePublished - Dec 1 2001

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