TY - JOUR
T1 - Bacteria renew an OLD protein to cleave host tRNAs and block phage translation
AU - Gibbs, Kyle D.
AU - LeRoux, Michele
N1 - Publisher Copyright:
© 2024 Elsevier Inc.
PY - 2024/10/9
Y1 - 2024/10/9
N2 - Anti-phage defenses must rapidly sense and respond to diverse viruses. A recent pair of papers in Nature reveal via structural and functional assays how the PARIS defense system, a recently discovered toxin-antitoxin system, senses phage-associated molecular patterns (PhAMPs), thereby activating an endonuclease toxin that cleaves tRNA to block phage replication.
AB - Anti-phage defenses must rapidly sense and respond to diverse viruses. A recent pair of papers in Nature reveal via structural and functional assays how the PARIS defense system, a recently discovered toxin-antitoxin system, senses phage-associated molecular patterns (PhAMPs), thereby activating an endonuclease toxin that cleaves tRNA to block phage replication.
UR - http://www.scopus.com/inward/record.url?scp=85206051961&partnerID=8YFLogxK
U2 - 10.1016/j.chom.2024.09.006
DO - 10.1016/j.chom.2024.09.006
M3 - Comment/debate
C2 - 39389024
AN - SCOPUS:85206051961
SN - 1931-3128
VL - 32
SP - 1639
EP - 1641
JO - Cell Host and Microbe
JF - Cell Host and Microbe
IS - 10
ER -