Abstract

Anti-phage defenses must rapidly sense and respond to diverse viruses. A recent pair of papers in Nature reveal via structural and functional assays how the PARIS defense system, a recently discovered toxin-antitoxin system, senses phage-associated molecular patterns (PhAMPs), thereby activating an endonuclease toxin that cleaves tRNA to block phage replication.

Original languageEnglish
Pages (from-to)1639-1641
Number of pages3
JournalCell Host and Microbe
Volume32
Issue number10
DOIs
StatePublished - Oct 9 2024

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