TY - JOUR
T1 - B cells and antibodies in CNS demyelinating disease
AU - Cross, Anne H.
AU - Trotter, John L.
AU - Lyons, Jeri Anne
N1 - Funding Information:
The authors were supported by grants from the National Multiple Sclerosis Society (RG3138-A-7 and RG3032-A-7). Jeri-Anne Lyons was a Fellow of the NMSS (FG-1259-A-1) during preparation of this manuscript.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - There is much evidence to implicate B cells, plasma cells, and their products in the pathogenesis of MS. Despite unequivocal evidence that the animal model for MS, EAE, is initiated by myelin-specific T cells, there is accumulating evidence of a role for B cells, plasma cells, and their products in EAE pathogenesis. The role(s) played by B cells, plasma cells, and antibodies in CNS inflammatory demyelinating diseases are likely to be multifactorial and complex, involving distinct and perhaps opposing roles for B cells versus antibody. (C) 2001 Elsevier Science B.V.
AB - There is much evidence to implicate B cells, plasma cells, and their products in the pathogenesis of MS. Despite unequivocal evidence that the animal model for MS, EAE, is initiated by myelin-specific T cells, there is accumulating evidence of a role for B cells, plasma cells, and their products in EAE pathogenesis. The role(s) played by B cells, plasma cells, and antibodies in CNS inflammatory demyelinating diseases are likely to be multifactorial and complex, involving distinct and perhaps opposing roles for B cells versus antibody. (C) 2001 Elsevier Science B.V.
KW - Antibody
KW - B cell
KW - Experimental autoimmune encephalomyelitis
KW - Multiple sclerosis
KW - Plasma cell
UR - http://www.scopus.com/inward/record.url?scp=0035212385&partnerID=8YFLogxK
U2 - 10.1016/S0165-5728(00)00409-4
DO - 10.1016/S0165-5728(00)00409-4
M3 - Review article
C2 - 11108928
AN - SCOPUS:0035212385
SN - 0165-5728
VL - 112
SP - 1
EP - 14
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
IS - 1-2
ER -