B cell-driven lymphangiogenesis in inflamed lymph nodes enhances dendritic cell mobilization

Véronique Angeli, Florent Ginhoux, Jaime Llodrà, Laurence Quemeneur, Paul S. Frenette, Mihaela Skobe, Rolf Jessberger, Miriam Merad, Gwendalyn J. Randolph

Research output: Contribution to journalArticlepeer-review

378 Scopus citations


Dendritic cell (DC) migration from the periphery to lymph nodes is regulated by the pattern of genes expressed by DCs themselves and by signals within the surrounding peripheral environment. Here, we report that DC mobilization can also be regulated by signals initiated within the downstream lymph nodes, particularly when lymph nodes enlarge as a consequence of immunization. Lymph node B lymphocytes orchestrate expansion of the lymphatic network within the immunized lymph node. This expanded network in turn supports increased DC migration from the periphery. These results reveal unique relationships between B cells, lymphatic vessels, and migratory DCs. Knowledge that DC migration from the periphery is augmented by B cell-dependent signals reveals new potential strategies to increase DC migration during vaccination.

Original languageEnglish
Pages (from-to)203-215
Number of pages13
Issue number2
StatePublished - Feb 2006


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