TY - JOUR
T1 - B and T lymphocyte attenuator regulates T cell survival in the lung
AU - Deppong, Christine
AU - Degnan, Jessica M.
AU - Murphy, Theresa L.
AU - Murphy, Kenneth M.
AU - Green, Jonathan M.
PY - 2008/9/1
Y1 - 2008/9/1
N2 - The initiation, intensity, and duration of T cell-directed inflammatory responses are dependent upon the coordination of both activating and inhibitory signals mediated by specific receptors on the T lymphocyte. The recently described receptor, B and T lymphocyte attenuator (BTLA), has been demonstrated to have an important role in limiting the duration of inflammation in a murine model of allergic asthma. In this study, we have examined the role of BTLA on the proliferation, recruitment, and survival of T cells in response to inhaled allergen. We find that there is decreased cell death in T cells from BTLAdeficient mice, whereas proliferation and recruitment to the lungs are unchanged. Thus, the regulation of cell death through BTLA signaling is a key determinant of the inflammatory response in the lung.
AB - The initiation, intensity, and duration of T cell-directed inflammatory responses are dependent upon the coordination of both activating and inhibitory signals mediated by specific receptors on the T lymphocyte. The recently described receptor, B and T lymphocyte attenuator (BTLA), has been demonstrated to have an important role in limiting the duration of inflammation in a murine model of allergic asthma. In this study, we have examined the role of BTLA on the proliferation, recruitment, and survival of T cells in response to inhaled allergen. We find that there is decreased cell death in T cells from BTLAdeficient mice, whereas proliferation and recruitment to the lungs are unchanged. Thus, the regulation of cell death through BTLA signaling is a key determinant of the inflammatory response in the lung.
UR - http://www.scopus.com/inward/record.url?scp=51549100281&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.181.5.2973
DO - 10.4049/jimmunol.181.5.2973
M3 - Article
C2 - 18713967
AN - SCOPUS:51549100281
SN - 0022-1767
VL - 181
SP - 2973
EP - 2979
JO - Journal of Immunology
JF - Journal of Immunology
IS - 5
ER -