TY - JOUR
T1 - Axonal Damage in Leukodystrophies
AU - Mar, Soe
AU - Noetzel, Michael
PY - 2010/4
Y1 - 2010/4
N2 - Recent advances in radioimaging and immunocytological techniques have enhanced investigations of neurometabolites and axons, giving rise to renewed interest in human white-matter disorders. A strong correlation between axonal loss and disability in some demyelination diseases (e.g., multiple sclerosis) led to several studies examining the mechanisms of axonal damage. We review the relationship between demyelination, axon loss, and neurologic progression, and the role of advanced neuroimaging in children with different types of leukodystrophies, i.e., X-linked adrenoleukodystrophy, metachromatic leukodysrtophy, Krabbe's disease, Pelizaeus-Merzbacher disease, and Alexander's disease.
AB - Recent advances in radioimaging and immunocytological techniques have enhanced investigations of neurometabolites and axons, giving rise to renewed interest in human white-matter disorders. A strong correlation between axonal loss and disability in some demyelination diseases (e.g., multiple sclerosis) led to several studies examining the mechanisms of axonal damage. We review the relationship between demyelination, axon loss, and neurologic progression, and the role of advanced neuroimaging in children with different types of leukodystrophies, i.e., X-linked adrenoleukodystrophy, metachromatic leukodysrtophy, Krabbe's disease, Pelizaeus-Merzbacher disease, and Alexander's disease.
UR - http://www.scopus.com/inward/record.url?scp=77949441794&partnerID=8YFLogxK
U2 - 10.1016/j.pediatrneurol.2009.08.011
DO - 10.1016/j.pediatrneurol.2009.08.011
M3 - Review article
C2 - 20304325
AN - SCOPUS:77949441794
SN - 0887-8994
VL - 42
SP - 239
EP - 242
JO - Pediatric Neurology
JF - Pediatric Neurology
IS - 4
ER -