Axonal cytoskeletal pathology in aged and diabetic human sympathetic autonomic ganglia

Robert E. Schmidt; Lucie N. Beaudet; Santiago B. Plurad; Denise A. Dorsey

doi:10.1016/S0006-8993(97)00806-8

Axonal cytoskeletal pathology in aged and diabetic human sympathetic autonomic ganglia

Robert E. Schmidt, Lucie N. Beaudet, Santiago B. Plurad, Denise A. Dorsey

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Abstract

Prevertebral sympathetic ganglia develop markedly enlarged argyrophilic neurites as a function of age, gender and diabetes. Immunolocalization studies demonstrate their preferential labeling with antisera to highly phosphorylated 200 kDa neurofilament (NF-H) epitopes, NPY, peripherin and synapsin I, but not to hypophosphorylated NF-M and NF-H or MAP-2. The immunophenotype of dystrophic neurites in conjunction with the results of histochemical and ultrastructural studies are consistent with the terminal axonal and/or synaptic origin of neuritic dystrophy in the sympathetic ganglia of aged and diabetic human subjects.

Original language	English
Pages (from-to)	375-383
Number of pages	9
Journal	Brain Research
Volume	769
Issue number	2
DOIs	https://doi.org/10.1016/S0006-8993(97)00806-8
State	Published - Sep 26 1997

Keywords

Neuroaxonal dystrophy
Neurofilament
Peripherin
Sympathetic ganglia

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10.1016/S0006-8993(97)00806-8

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title = "Axonal cytoskeletal pathology in aged and diabetic human sympathetic autonomic ganglia",

abstract = "Prevertebral sympathetic ganglia develop markedly enlarged argyrophilic neurites as a function of age, gender and diabetes. Immunolocalization studies demonstrate their preferential labeling with antisera to highly phosphorylated 200 kDa neurofilament (NF-H) epitopes, NPY, peripherin and synapsin I, but not to hypophosphorylated NF-M and NF-H or MAP-2. The immunophenotype of dystrophic neurites in conjunction with the results of histochemical and ultrastructural studies are consistent with the terminal axonal and/or synaptic origin of neuritic dystrophy in the sympathetic ganglia of aged and diabetic human subjects.",

keywords = "Neuroaxonal dystrophy, Neurofilament, Peripherin, Sympathetic ganglia",

author = "Schmidt, {Robert E.} and Beaudet, {Lucie N.} and Plurad, {Santiago B.} and Dorsey, {Denise A.}",

note = "Funding Information: We would like to thank Drs. John Trojanowski and Mike Landt for gifts of antibodies and Drs. Kevin Roth and Steven Carroll for helpful discussions. This work was supported by NIH Awards AG10299 and DK19645.",

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doi = "10.1016/S0006-8993(97)00806-8",

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T1 - Axonal cytoskeletal pathology in aged and diabetic human sympathetic autonomic ganglia

AU - Schmidt, Robert E.

AU - Beaudet, Lucie N.

AU - Plurad, Santiago B.

AU - Dorsey, Denise A.

N1 - Funding Information: We would like to thank Drs. John Trojanowski and Mike Landt for gifts of antibodies and Drs. Kevin Roth and Steven Carroll for helpful discussions. This work was supported by NIH Awards AG10299 and DK19645.

PY - 1997/9/26

Y1 - 1997/9/26

N2 - Prevertebral sympathetic ganglia develop markedly enlarged argyrophilic neurites as a function of age, gender and diabetes. Immunolocalization studies demonstrate their preferential labeling with antisera to highly phosphorylated 200 kDa neurofilament (NF-H) epitopes, NPY, peripherin and synapsin I, but not to hypophosphorylated NF-M and NF-H or MAP-2. The immunophenotype of dystrophic neurites in conjunction with the results of histochemical and ultrastructural studies are consistent with the terminal axonal and/or synaptic origin of neuritic dystrophy in the sympathetic ganglia of aged and diabetic human subjects.

AB - Prevertebral sympathetic ganglia develop markedly enlarged argyrophilic neurites as a function of age, gender and diabetes. Immunolocalization studies demonstrate their preferential labeling with antisera to highly phosphorylated 200 kDa neurofilament (NF-H) epitopes, NPY, peripherin and synapsin I, but not to hypophosphorylated NF-M and NF-H or MAP-2. The immunophenotype of dystrophic neurites in conjunction with the results of histochemical and ultrastructural studies are consistent with the terminal axonal and/or synaptic origin of neuritic dystrophy in the sympathetic ganglia of aged and diabetic human subjects.

KW - Neuroaxonal dystrophy

KW - Neurofilament

KW - Peripherin

KW - Sympathetic ganglia

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Axonal cytoskeletal pathology in aged and diabetic human sympathetic autonomic ganglia

Abstract

Keywords

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