Axon Self-Destruction: New Links among SARM1, MAPKs, and NAD+ Metabolism

Josiah Gerdts, Daniel W. Summers, Jeffrey Milbrandt, Aaron DiAntonio

Research output: Contribution to journalReview articlepeer-review

150 Scopus citations

Abstract

Wallerian axon degeneration is a form of programmed subcellular death that promotes axon breakdown in disease and injury. Active degeneration requires SARM1 and MAP kinases, including DLK, while the NAD+ synthetic enzyme NMNAT2 prevents degeneration. New studies reveal that these pathways cooperate in a locally mediated axon destruction program, with NAD+ metabolism playing a central role. Here, we review the biology of Wallerian-type axon degeneration and discuss the most recent findings, with special emphasis on critical signaling events and their potential as therapeutic targets for axonopathy.

Original languageEnglish
Pages (from-to)449-460
Number of pages12
JournalNeuron
Volume89
Issue number3
DOIs
StatePublished - Feb 3 2016

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