@article{320d73882bdc412f810d0c5e121c80f0,
title = "Axon Regeneration in the Mammalian Optic Nerve",
abstract = "The damage or loss of retinal ganglion cells (RGCs) and their axons accounts for the visual functional defects observed after traumatic injury, in degenerative diseases such as glaucoma, or in compressive optic neuropathies such as from optic glioma. By using optic nerve crush injury models, recent studies have revealed the cellular and molecular logic behind the regenerative failure of injured RGC axons in adult mammals and suggested several strategies with translational potential. This review summarizes these findings and discusses challenges for developing clinically applicable neural repair strategies.",
keywords = "KLF, axon regeneration, mTOR, oncomodulin, retinal ganglion cells, survival",
author = "Williams, {Philip R.} and Benowitz, {Larry I.} and Goldberg, {Jeffrey L.} and Zhigang He",
note = "Funding Information: This work was supported by National Institutes of Health and National Eye Institute grants P30-EY026877 (to J.L.G.), R01-EY026766 (to J.L.G.), R01EY024481 (to L.I.B.), R01EY027881 (to L.I.B.), R01EY026939 (to Z.H.), and R01EY021526 (to Z.H.); funding from the Dr.Miriam and Sheldon G. Adelson Medical Research Foundation (to L.I.B. and Z.H.), the Medical Technology Enterprise Consortium (to J.L.G., L.I.B., and Z.H.), the Gilbert Vision Restoration Initiative (to J.L.G., L.I.B., and Z.H.), and Research to Prevent Blindness, Inc. (to P.R.W. and J.L.G.); US Department of Defense Congressionally Directed Medical Research Program grant W81XWH-16-1-0043 (to L.I.B. and J.L.G.); and National Institute of Child Health and Development Intellectual and Developmental Disabilities Research Centers grant HD018655 (to Z.H. and L.I.B.). Publisher Copyright: {\textcopyright} 2020 Annual Reviews Inc.. All rights reserved.",
year = "2020",
month = sep,
day = "15",
doi = "10.1146/annurev-vision-022720-094953",
language = "English",
volume = "6",
pages = "195--213",
journal = "Annual Review of Vision Science",
issn = "2374-4642",
}