Axon Regeneration in the Mammalian Optic Nerve

Philip R. Williams, Larry I. Benowitz, Jeffrey L. Goldberg, Zhigang He

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations

Abstract

The damage or loss of retinal ganglion cells (RGCs) and their axons accounts for the visual functional defects observed after traumatic injury, in degenerative diseases such as glaucoma, or in compressive optic neuropathies such as from optic glioma. By using optic nerve crush injury models, recent studies have revealed the cellular and molecular logic behind the regenerative failure of injured RGC axons in adult mammals and suggested several strategies with translational potential. This review summarizes these findings and discusses challenges for developing clinically applicable neural repair strategies.

Original languageEnglish
Pages (from-to)195-213
Number of pages19
JournalAnnual Review of Vision Science
Volume6
DOIs
StatePublished - Sep 15 2020

Keywords

  • KLF
  • axon regeneration
  • mTOR
  • oncomodulin
  • retinal ganglion cells
  • survival

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