TY - JOUR
T1 - Axon position within the corpus callosum determines contralateral cortical projection
AU - Zhou, Jing
AU - Wen, Yunqing
AU - She, Liang
AU - Sui, Ya Nan
AU - Liu, Lu
AU - Richards, Linda J.
AU - Poo, Mu Ming
PY - 2013/7/16
Y1 - 2013/7/16
N2 - How developing axons in the corpus callosum (CC) achieve their homotopic projection to the contralateral cortex remains unclear.We found that axonal position within the CC plays a critical role in this projection. Labeling of nearby callosal axons in mice showed that callosal axons were segregated in an orderly fashion, with those from more medial cerebral cortex located more dorsally and subsequently projecting to more medial contralateral cortical regions. The normal axonal order within the CC was grossly disturbed when semaphorin3A/neuropilin-1 signaling was disrupted. However, the order in which axonswere positioned within the CC still determined their contralateral projection, causing a severe disruption of the homotopic contralateral projection that persisted at postnatal day 30, when the normal developmental refinement of contralateral projections is completed in wild-type (WT) mice. Thus, the orderly positioning of axons within the CC is a primary determinant of how homotopic interhemispheric projections form in the contralateral cortex.
AB - How developing axons in the corpus callosum (CC) achieve their homotopic projection to the contralateral cortex remains unclear.We found that axonal position within the CC plays a critical role in this projection. Labeling of nearby callosal axons in mice showed that callosal axons were segregated in an orderly fashion, with those from more medial cerebral cortex located more dorsally and subsequently projecting to more medial contralateral cortical regions. The normal axonal order within the CC was grossly disturbed when semaphorin3A/neuropilin-1 signaling was disrupted. However, the order in which axonswere positioned within the CC still determined their contralateral projection, causing a severe disruption of the homotopic contralateral projection that persisted at postnatal day 30, when the normal developmental refinement of contralateral projections is completed in wild-type (WT) mice. Thus, the orderly positioning of axons within the CC is a primary determinant of how homotopic interhemispheric projections form in the contralateral cortex.
KW - Axon Development
KW - Axon Fiber Order
KW - Cortical Axon Guidance
KW - Cortical Development
UR - http://www.scopus.com/inward/record.url?scp=84880371264&partnerID=8YFLogxK
U2 - 10.1073/pnas.1310233110
DO - 10.1073/pnas.1310233110
M3 - Article
C2 - 23812756
AN - SCOPUS:84880371264
SN - 0027-8424
VL - 110
SP - E2714-E2723
JO - Proceedings of the National Academy of Sciences of the United States of America
JF - Proceedings of the National Academy of Sciences of the United States of America
IS - 29
ER -