Avian W and mammalian y chromosomes convergently retained dosage-sensitive regulators

Daniel W. Bellott, Helen Skaletsky, Ting Jan Cho, Laura Brown, Devin Locke, Nancy Chen, Svetlana Galkina, Tatyana Pyntikova, Natalia Koutseva, Tina Graves, Colin Kremitzki, Wesley C. Warren, Andrew G. Clark, Elena Gaginskaya, Richard K. Wilson, David C. Page

Research output: Contribution to journalArticlepeer-review

50 Scopus citations

Abstract

After birds diverged from mammals, different ancestral autosomes evolved into sex chromosomes in each lineage. In birds, females are ZW and males are ZZ, but in mammals females are XX and males are XY. We sequenced the chicken W chromosome, compared its gene content with our reconstruction of the ancestral autosomes, and followed the evolutionary trajectory of ancestral W-linked genes across birds. Avian W chromosomes evolved in parallel with mammalian Y chromosomes, preserving ancestral genes through selection to maintain the dosage of broadly expressed regulators of key cellular processes. We propose that, like the human Y chromosome, the chicken W chromosome is essential for embryonic viability of the heterogametic sex. Unlike other sequenced sex chromosomes, the chicken W chromosome did not acquire and amplify genes specifically expressed in reproductive tissues. We speculate that the pressures that drive the acquisition of reproduction-related genes on sex chromosomes may be specific to the male germ line.

Original languageEnglish
Pages (from-to)387-394
Number of pages8
JournalNature Genetics
Volume49
Issue number3
DOIs
StatePublished - Mar 1 2017

Fingerprint Dive into the research topics of 'Avian W and mammalian y chromosomes convergently retained dosage-sensitive regulators'. Together they form a unique fingerprint.

Cite this