Autosomal-dominant Alzheimer's disease: A review and proposal for the prevention of Alzheimer's disease

Randall J. Bateman; Paul S. Aisen; Bart De Strooper; Nick C. Fox; Cynthia A. Lemere; John M. Ringman; Stephen Salloway; Reisa A. Sperling; Manfred Windisch; Chengjie Xiong

doi:10.1186/alzrt59

Autosomal-dominant Alzheimer's disease: A review and proposal for the prevention of Alzheimer's disease

Randall J. Bateman
, Paul S. Aisen
, Bart De Strooper
, Nick C. Fox
, Cynthia A. Lemere
, John M. Ringman
, Stephen Salloway
, Reisa A. Sperling
, Manfred Windisch
, Chengjie Xiong

Research output: Contribution to journal › Review article › peer-review

473 Scopus citations

Abstract

Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.

Original language	English
Article number	35
Journal	Alzheimer's Research and Therapy
Volume	2
Issue number	6
DOIs	https://doi.org/10.1186/alzrt59
State	Published - 2011

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10.1186/alzrt59

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@article{489e97fab9ab47ac87c740585868a154,

title = "Autosomal-dominant Alzheimer's disease: A review and proposal for the prevention of Alzheimer's disease",

abstract = "Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.",

author = "Bateman, \{Randall J.\} and Aisen, \{Paul S.\} and \{De Strooper\}, Bart and Fox, \{Nick C.\} and Lemere, \{Cynthia A.\} and Ringman, \{John M.\} and Stephen Salloway and Sperling, \{Reisa A.\} and Manfred Windisch and Chengjie Xiong",

note = "Funding Information: BDS is a consultant for Janssen Pharmaceutica, Beerse, Envivo Pharmaceuticals, Boston and Remynd NV, Leuven. He also receives research funding from Janssen Pharmaceutica, Beerse. RAS has consulted for Janssen, Pfizer, Elan, Bayer, Bristol-Myers-Squibb. The authors declare no other competing interests. Funding Information: The authors are grateful to the participants for their time and eff ort in contributing to the body of knowledge reviewed. The present work was supported by grants from the US National Institutes of Health grants U-01 AG032438 and also grants from an anonymous foundation. NCF is supported by the UK National Institute for Health Research and Medical Research Council. BDS is supported by a Methusalem grant from the Flanders government and the KULeuven. The authors thank Karen Dodson for her insightful editing of the manuscript.",

year = "2011",

doi = "10.1186/alzrt59",

language = "English",

volume = "2",

journal = "Alzheimer's Research and Therapy",

issn = "1758-9193",

number = "6",

}

TY - JOUR

T1 - Autosomal-dominant Alzheimer's disease

T2 - A review and proposal for the prevention of Alzheimer's disease

AU - Bateman, Randall J.

AU - Aisen, Paul S.

AU - De Strooper, Bart

AU - Fox, Nick C.

AU - Lemere, Cynthia A.

AU - Ringman, John M.

AU - Salloway, Stephen

AU - Sperling, Reisa A.

AU - Windisch, Manfred

AU - Xiong, Chengjie

N1 - Funding Information: BDS is a consultant for Janssen Pharmaceutica, Beerse, Envivo Pharmaceuticals, Boston and Remynd NV, Leuven. He also receives research funding from Janssen Pharmaceutica, Beerse. RAS has consulted for Janssen, Pfizer, Elan, Bayer, Bristol-Myers-Squibb. The authors declare no other competing interests. Funding Information: The authors are grateful to the participants for their time and eff ort in contributing to the body of knowledge reviewed. The present work was supported by grants from the US National Institutes of Health grants U-01 AG032438 and also grants from an anonymous foundation. NCF is supported by the UK National Institute for Health Research and Medical Research Council. BDS is supported by a Methusalem grant from the Flanders government and the KULeuven. The authors thank Karen Dodson for her insightful editing of the manuscript.

PY - 2011

Y1 - 2011

N2 - Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.

AB - Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.

UR - https://www.scopus.com/pages/publications/78651266932

U2 - 10.1186/alzrt59

DO - 10.1186/alzrt59

M3 - Review article

C2 - 21211070

AN - SCOPUS:78651266932

SN - 1758-9193

VL - 2

JO - Alzheimer's Research and Therapy

JF - Alzheimer's Research and Therapy

IS - 6

M1 - 35

ER -

Autosomal-dominant Alzheimer's disease: A review and proposal for the prevention of Alzheimer's disease

Abstract

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