Autosomal-dominant Alzheimer's disease: A review and proposal for the prevention of Alzheimer's disease

Randall J. Bateman, Paul S. Aisen, Bart De Strooper, Nick C. Fox, Cynthia A. Lemere, John M. Ringman, Stephen Salloway, Reisa A. Sperling, Manfred Windisch, Chengjie Xiong

Research output: Contribution to journalReview article

244 Scopus citations

Abstract

Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.

Original languageEnglish
Article number35
JournalAlzheimer's Research and Therapy
Volume2
Issue number6
DOIs
StatePublished - Jan 1 2011

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