TY - JOUR
T1 - Autosomal-dominant Alzheimer's disease
T2 - A review and proposal for the prevention of Alzheimer's disease
AU - Bateman, Randall J.
AU - Aisen, Paul S.
AU - De Strooper, Bart
AU - Fox, Nick C.
AU - Lemere, Cynthia A.
AU - Ringman, John M.
AU - Salloway, Stephen
AU - Sperling, Reisa A.
AU - Windisch, Manfred
AU - Xiong, Chengjie
N1 - Funding Information:
BDS is a consultant for Janssen Pharmaceutica, Beerse, Envivo Pharmaceuticals, Boston and Remynd NV, Leuven. He also receives research funding from Janssen Pharmaceutica, Beerse. RAS has consulted for Janssen, Pfizer, Elan, Bayer, Bristol-Myers-Squibb. The authors declare no other competing interests.
Funding Information:
The authors are grateful to the participants for their time and eff ort in contributing to the body of knowledge reviewed. The present work was supported by grants from the US National Institutes of Health grants U-01 AG032438 and also grants from an anonymous foundation. NCF is supported by the UK National Institute for Health Research and Medical Research Council. BDS is supported by a Methusalem grant from the Flanders government and the KULeuven. The authors thank Karen Dodson for her insightful editing of the manuscript.
PY - 2011
Y1 - 2011
N2 - Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.
AB - Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.
UR - http://www.scopus.com/inward/record.url?scp=78651266932&partnerID=8YFLogxK
U2 - 10.1186/alzrt59
DO - 10.1186/alzrt59
M3 - Review article
C2 - 21211070
AN - SCOPUS:78651266932
SN - 1758-9193
VL - 2
JO - Alzheimer's Research and Therapy
JF - Alzheimer's Research and Therapy
IS - 6
M1 - 35
ER -