Autoregulation of B cell growth by an immunoglobulin M autoantibody

J. M. Kiely, J. Braun, E. R. Unanue

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

This study documents the autoregulation of B cell growth by an IgM autoantibody. This autoantibody is secreted by B lymphocytes upon stimulation by polyclonal activators and is identified by its potent inhibition of B cell growth induced by these agents (endotoxin, Fc fragment of human γ-globulin, Mycoplasma bovorrhinis, and anti-mouse Ig). The autoantibody specifically affects B cells: there was no effect on mitogen- or antigen-induced T cell proliferation and of responses to interleukin 1, interleukin 2, or interferon. Nonspecific effects were excluded by the ineffectiveness of serum and myeloma IgM. Also, IgG-IgM immune complexes were excluded. The binding specificity of the IgM autoantibody is not yet defined but appears to be a B cell surface structure distinct from membrane Ig. The autoantibody constitutes a ubiquitous, autoregulatory influence on B cell growth, which may be an important component in physiologic and pathologic states of B cell homeostasis.

Original languageEnglish
Pages (from-to)1040-1045
Number of pages6
JournalJournal of Immunology
Volume135
Issue number2
StatePublished - Dec 1 1985

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