TY - JOUR
T1 - Autoradiography-based, three-dimensional calculation of dose rate for murine, human-tumor xenografts
AU - Koral, Kenneth F.
AU - Kwok, Cheuk S.
AU - Yang, Farley E.
AU - Brown, Raya S.
AU - Sisson, James C.
AU - Wahl, Richard L.
PY - 1993/11
Y1 - 1993/11
N2 - A Fast Fourier Transform method for calculating the three-dimensional dose rate distribution for murine, human-tumor xenografts is outlined. The required input includes evenly-spaced activity slices which span the tumor. Numerical values in these slices are determined by quantitative 125I autoradiography. For the absorbed dose-rate calculation, we assume the activity from both 131I- and 90Y-labeled radiopharmaceuticals would be distributed as is measured with the 125I label. Two example cases are presented: an ovarian-carcinoma xenograft with an IgG 2ak monoclonal antibody and a neuroblastoma xenograft with meta-iodobenzylguanidine (MIBG). Considering all the volume elements in a tumor, we show, by comparison of histograms and also relative standard deviations, that the measured 125I activity and the calculated 131I dose-rate distributions, are similarly non-uniform and that they are more non-uniform than the calculated 90Y dose-rate distribution. However, the maximum-to-minimum ratio, another measure of non-uniformity, decreases by roughly an order of magnitude from one distribution to the next in the order given above.
AB - A Fast Fourier Transform method for calculating the three-dimensional dose rate distribution for murine, human-tumor xenografts is outlined. The required input includes evenly-spaced activity slices which span the tumor. Numerical values in these slices are determined by quantitative 125I autoradiography. For the absorbed dose-rate calculation, we assume the activity from both 131I- and 90Y-labeled radiopharmaceuticals would be distributed as is measured with the 125I label. Two example cases are presented: an ovarian-carcinoma xenograft with an IgG 2ak monoclonal antibody and a neuroblastoma xenograft with meta-iodobenzylguanidine (MIBG). Considering all the volume elements in a tumor, we show, by comparison of histograms and also relative standard deviations, that the measured 125I activity and the calculated 131I dose-rate distributions, are similarly non-uniform and that they are more non-uniform than the calculated 90Y dose-rate distribution. However, the maximum-to-minimum ratio, another measure of non-uniformity, decreases by roughly an order of magnitude from one distribution to the next in the order given above.
UR - http://www.scopus.com/inward/record.url?scp=0027374443&partnerID=8YFLogxK
U2 - 10.1016/0969-8051(93)90090-H
DO - 10.1016/0969-8051(93)90090-H
M3 - Article
C2 - 8298569
AN - SCOPUS:0027374443
SN - 0969-8051
VL - 20
SP - 901
EP - 909
JO - Nuclear Medicine and Biology
JF - Nuclear Medicine and Biology
IS - 8
ER -