Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction

Mahmoud Abdellatif; Francisco Vasques-Nóvoa; Viktoria Trummer-Herbst; Sylvère Durand; Franziska Koser; Moydul Islam; Jihoon Nah; Eun Ah Sung; Ruli Feng; Fanny Aprahamian; Andreas Prokesch; Pablo Zardoya-Laguardia; Junichi Sadoshima; Abhinav Diwan; Wolfgang A. Linke; João Pedro Ferreira; Guido Kroemer; Simon Sedej

doi:10.1093/eurheartj/ehaf062

Autophagy is required for the therapeutic effects of the NAD⁺ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction

Mahmoud Abdellatif, Francisco Vasques-Nóvoa, Viktoria Trummer-Herbst, Sylvère Durand, Franziska Koser, Moydul Islam, Jihoon Nah, Eun Ah Sung, Ruli Feng, Fanny Aprahamian, Andreas Prokesch, Pablo Zardoya-Laguardia, Junichi Sadoshima, Abhinav Diwan, Wolfgang A. Linke, João Pedro Ferreira, Guido Kroemer, Simon Sedej

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Original language	English
Pages (from-to)	1863-1866
Number of pages	4
Journal	European heart journal
Volume	46
Issue number	19
DOIs	https://doi.org/10.1093/eurheartj/ehaf062
State	Published - May 14 2025

Keywords

Autophagy
HFpEF
Metabolic cardiomyopathy
Mitophagy
NAD+ metabolism
Obesity

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10.1093/eurheartj/ehaf062

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Abdellatif, M., Vasques-Nóvoa, F., Trummer-Herbst, V., Durand, S., Koser, F., Islam, M., Nah, J., Sung, E. A., Feng, R., Aprahamian, F., Prokesch, A., Zardoya-Laguardia, P., Sadoshima, J., Diwan, A., Linke, W. A., Ferreira, J. P., Kroemer, G., & Sedej, S. (2025). Autophagy is required for the therapeutic effects of the NAD⁺ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction. European heart journal, 46(19), 1863-1866. https://doi.org/10.1093/eurheartj/ehaf062

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title = "Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction",

keywords = "Autophagy, HFpEF, Metabolic cardiomyopathy, Mitophagy, NAD+ metabolism, Obesity",

author = "Mahmoud Abdellatif and Francisco Vasques-N{\'o}voa and Viktoria Trummer-Herbst and Sylv{\`e}re Durand and Franziska Koser and Moydul Islam and Jihoon Nah and Sung, {Eun Ah} and Ruli Feng and Fanny Aprahamian and Andreas Prokesch and Pablo Zardoya-Laguardia and Junichi Sadoshima and Abhinav Diwan and Linke, {Wolfgang A.} and Ferreira, {Jo{\~a}o Pedro} and Guido Kroemer and Simon Sedej",

year = "2025",

month = may,

day = "14",

doi = "10.1093/eurheartj/ehaf062",

language = "English",

volume = "46",

pages = "1863--1866",

journal = "European heart journal",

issn = "0195-668X",

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Abdellatif, M, Vasques-Nóvoa, F, Trummer-Herbst, V, Durand, S, Koser, F, Islam, M, Nah, J, Sung, EA, Feng, R, Aprahamian, F, Prokesch, A, Zardoya-Laguardia, P, Sadoshima, J, Diwan, A, Linke, WA, Ferreira, JP, Kroemer, G & Sedej, S 2025, 'Autophagy is required for the therapeutic effects of the NAD⁺ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction', European heart journal, vol. 46, no. 19, pp. 1863-1866. https://doi.org/10.1093/eurheartj/ehaf062

Autophagy is required for the therapeutic effects of the NAD⁺ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction. / Abdellatif, Mahmoud; Vasques-Nóvoa, Francisco; Trummer-Herbst, Viktoria et al.
In: European heart journal, Vol. 46, No. 19, 14.05.2025, p. 1863-1866.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction

AU - Abdellatif, Mahmoud

AU - Vasques-Nóvoa, Francisco

AU - Trummer-Herbst, Viktoria

AU - Durand, Sylvère

AU - Koser, Franziska

AU - Islam, Moydul

AU - Nah, Jihoon

AU - Sung, Eun Ah

AU - Feng, Ruli

AU - Aprahamian, Fanny

AU - Prokesch, Andreas

AU - Zardoya-Laguardia, Pablo

AU - Sadoshima, Junichi

AU - Diwan, Abhinav

AU - Linke, Wolfgang A.

AU - Ferreira, João Pedro

AU - Kroemer, Guido

AU - Sedej, Simon

PY - 2025/5/14

Y1 - 2025/5/14

KW - Autophagy

KW - HFpEF

KW - Metabolic cardiomyopathy

KW - Mitophagy

KW - NAD+ metabolism

KW - Obesity

UR - http://www.scopus.com/inward/record.url?scp=105005315102&partnerID=8YFLogxK

U2 - 10.1093/eurheartj/ehaf062

DO - 10.1093/eurheartj/ehaf062

M3 - Article

C2 - 39995248

AN - SCOPUS:105005315102

SN - 0195-668X

VL - 46

SP - 1863

EP - 1866

JO - European heart journal

JF - European heart journal

IS - 19

ER -

Autophagy is required for the therapeutic effects of the NAD+ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction

Keywords

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Autophagy is required for the therapeutic effects of the NAD⁺ precursor nicotinamide in obesity-related heart failure with preserved ejection fraction