Autophagy in mammalian antiviral immunity

Anthony Orvedahl, Beth Levine

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

28 Scopus citations

Abstract

Autophagy plays diverse roles in cellular adaptation to stress and promotes vital housekeeping functions by recycling unused or damaged organelles and proteins. As an innate immune defense pathway, autophagy also protects against infection with diverse pathogens, including viruses. Autophagy combats infections with both RNA and DNA viruses, and may function by degrading viral components, by promoting the survival of virally infected cells, and/or by activating innate and adaptive immunity. Viruses have evolved counter-mechanisms to evade host autophagy in order to promote their own survival. This chapter will highlight recent advances and unanswered questions relating to autophagy in mammalian antiviral immunity.

Original languageEnglish
Title of host publicationAutophagy in Infection and Immunity
PublisherSpringer Verlag
Pages267-285
Number of pages19
Edition1
ISBN (Print)9783642003011
DOIs
StatePublished - 2009

Publication series

NameCurrent Topics in Microbiology and Immunology
Number1
Volume335
ISSN (Print)0070-217X

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