Autophagy for cancer therapy through inhibition of pro-apoptotic proteins and mammalian target of rapamycin signaling

Keyphrases

• Cancer Therapy 100%
• Autophagy 100%
• Mammalian Target of Rapamycin Signaling 100%
• Anti-apoptotic Proteins 100%
• RAD001 33%
• Apoptosis 22%
• ATG5 22%
• Beclin-1 22%
• MTOR Inhibitor 22%
• Radiosensitive 22%
• Overexpression 11%
• Cancer Cells 11%
• In Cancer 11%
• Tumor Cell Lines 11%
• Cancer Patients 11%
• Cancer Model 11%
• ATG12 11%
• Small Interfering RNA (siRNA) 11%
• Radiation Effects 11%
• Cell Death Pathways 11%
• Human Breast Cancer Cells 11%
• Molecular Events 11%
• Novel Pathways 11%
• Significant Benefit 11%
• Fibroblast Cell Line 11%
• Mouse Embryonic Fibroblasts 11%
• Radiosensitization 11%
• Radioresistant 11%
• Autophagy-related Proteins 11%
• AKT/mammalian Target of Rapamycin 11%
• Embryonal Tumor 11%
• Human Lung Cancer Cells 11%
• Gamma Irradiation 11%
• Isogenic Cell Lines 11%
• Apoptotic Induction 11%
• Alternative Cell Death 11%

Pharmacology, Toxicology and Pharmaceutical Science

• Malignant Neoplasm 100%
• Mammalian Target of Rapamycin 100%
• Everolimus 100%
• Beclin 1 66%
• Mammalian Target of Rapamycin Inhibitor 66%
• Neoplasm 33%
• Small Interfering RNA 33%
• Breast Cancer 33%
• Cancer Model 33%
• Lung Cancer 33%
• Protein Kinase B 33%
• Autophagy Related Protein 5 33%

Biochemistry, Genetics and Molecular Biology

• Autophagy 100%
• Mechanistic Target of Rapamycin 100%
• Wild Type 33%
• Cancer Cell 22%
• Sensitization 22%
• ATG5 22%
• Programmed Cell Death 22%
• Upregulation 11%
• Small Interfering RNA 11%
• Cell Death 11%
• Radiosensitization 11%
• Gamma Radiation 11%
• ATG12 11%
• Akt/mTOR Signaling 11%
• Fibroblast 11%
• Cancer Model 11%