TY - JOUR
T1 - Autophagy
T2 - A core cellular process with emerging links to pulmonary disease
AU - Haspel, Jeffrey A.
AU - Choi, Augustine M.K.
PY - 2011/12/1
Y1 - 2011/12/1
N2 - Autophagy is a highly conservedhomeostatic pathway by which cells transport damaged proteins and organelles to lysosomes for degradation. Dysregulation of autophagy contributes to the pathogenesis of clinically important disorders in a variety of organ systems but, until recently, little was known about its relationship to diseases of the lung. However, there is now growing evidence at the basic research level that autophagy is linked to the pathogenesis of important pulmonary disorders such as chronic obstructive pulmonary disease, cystic fibrosis, and tuberculosis. In this review, we provide an introduction to the field of autophagy research geared to clinical and research pulmonologists. We focus on the best-studied autophagic mechanism, macroautophagy, and summarize studies that link the regulation of this pathway to pulmonary disease. Last, we offer our perspective on how a better understanding of macroautophagy might be used for designing novel therapies for pulmonary disorders.
AB - Autophagy is a highly conservedhomeostatic pathway by which cells transport damaged proteins and organelles to lysosomes for degradation. Dysregulation of autophagy contributes to the pathogenesis of clinically important disorders in a variety of organ systems but, until recently, little was known about its relationship to diseases of the lung. However, there is now growing evidence at the basic research level that autophagy is linked to the pathogenesis of important pulmonary disorders such as chronic obstructive pulmonary disease, cystic fibrosis, and tuberculosis. In this review, we provide an introduction to the field of autophagy research geared to clinical and research pulmonologists. We focus on the best-studied autophagic mechanism, macroautophagy, and summarize studies that link the regulation of this pathway to pulmonary disease. Last, we offer our perspective on how a better understanding of macroautophagy might be used for designing novel therapies for pulmonary disorders.
KW - Autophagy
KW - Chronic obstructive pulmonary disease
KW - Disease
KW - Lung
KW - Macroautophagy
UR - http://www.scopus.com/inward/record.url?scp=80655130404&partnerID=8YFLogxK
U2 - 10.1164/rccm.201106-0966CI
DO - 10.1164/rccm.201106-0966CI
M3 - Review article
C2 - 21836133
AN - SCOPUS:80655130404
SN - 1073-449X
VL - 184
SP - 1237
EP - 1246
JO - American journal of respiratory and critical care medicine
JF - American journal of respiratory and critical care medicine
IS - 11
ER -