Autophagy: A core cellular process with emerging links to pulmonary disease

Jeffrey A. Haspel, Augustine M.K. Choi

Research output: Contribution to journalReview article

47 Scopus citations

Abstract

Autophagy is a highly conservedhomeostatic pathway by which cells transport damaged proteins and organelles to lysosomes for degradation. Dysregulation of autophagy contributes to the pathogenesis of clinically important disorders in a variety of organ systems but, until recently, little was known about its relationship to diseases of the lung. However, there is now growing evidence at the basic research level that autophagy is linked to the pathogenesis of important pulmonary disorders such as chronic obstructive pulmonary disease, cystic fibrosis, and tuberculosis. In this review, we provide an introduction to the field of autophagy research geared to clinical and research pulmonologists. We focus on the best-studied autophagic mechanism, macroautophagy, and summarize studies that link the regulation of this pathway to pulmonary disease. Last, we offer our perspective on how a better understanding of macroautophagy might be used for designing novel therapies for pulmonary disorders.

Original languageEnglish
Pages (from-to)1237-1246
Number of pages10
JournalAmerican journal of respiratory and critical care medicine
Volume184
Issue number11
DOIs
StatePublished - Dec 1 2011
Externally publishedYes

Keywords

  • Autophagy
  • Chronic obstructive pulmonary disease
  • Disease
  • Lung
  • Macroautophagy

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