TY - JOUR
T1 - Autophagic flux and oxidative capacity of skeletal muscles during acute starvation
AU - Mofarrahi, Mahroo
AU - Guo, Yeting
AU - Haspel, Jeffrey A.
AU - Choi, Augustine M.K.
AU - Davis, Elaine C.
AU - Gouspillou, Gilles
AU - Hepple, Russell T.
AU - Godin, Richard
AU - Burelle, Yan
AU - Hussain, Sabah N.A.
N1 - Funding Information:
This work was funded by a grant awarded to SNAH from the Canadian Institutes of Health Research (CIHR) and by a grant awarded to SNAH from the Natural Sciences and Engineering Research Council of Canada (NSERC).
PY - 2013/10
Y1 - 2013/10
N2 - ACTB, actin, beta; AKT, v-akt murine thymoma viral oncogene homolog; AMPK, 5'AMP-activated protein kinase; ANOVA, analysis of variance; ATG4B, autophagy-related 4B, cysteine peptidase; ATG5, autophagy-related 5; ATG7, autophagy-related 7; ATG12, autophagy-related 12; ATG13, autophagy-related 13; ATG14, autophagy-related 14; BCL2/ PPP1R50, B-cell CLL/lymphoma 2; BCL2L11/BIM, BCL2-like 11 (apoptosis facilitator); BECN1, Beclin 1, autophagy related; BNIP3, BCL2/adenovirus E1B 19 kDa interacting protein 3; BNIP3L/NIX, BCL2/adenovirus E1B 19 kDa interacting protein 3-like; DIA, diaphragm; EDL, extensor digitorium longus; EDTA, ethylenediaminetetraacetic acid; DTT, dithioreitol; FBXO32/ ATROGIN1, F-box protein 32; FOXO1, forkhead box O1; FOXO3, forkhead box O3; FOXO4, forkhead box O4; GABARAPL1, GABA(A) receptor-associated protein like 1; GP, gastrocnemius-plantaris; i.p., intraperitoneal; LAMP2A, lysosomal-associated membrane protein 2A; MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 beta; MTORC1, mechanistic target of rapamycin complex 1; PARK2, parkinson protein 2, E3 ubiquitin protein ligase (parkin); PBS, phosphate-buffered saline; PIK3C3, phosphatidylinositol 3-kinase, catalytic subunit type 3; PMSF, phenylmethylsulfonyl fluoride; PVDF, polyvinylidene difluoride ; RB1CC1/FIP200, RB1-inducible coiled-coil 1; ROS, reactive oxygen species; RPS6, ribosomal protein S6; RPS6KB1, ribosomal protein S6 kinase, 70 kDa, polypeptide 1; SEM, standard error of the mean; SOD1, superoxide dismutase 1, soluble; SOL, soleus; SQSTM1/p62, sequestosome 1; TA, tibialis anterior; TRAF6/RNF85, TNF receptor-associated factor 6, E3 ubiquitin protein ligase; TUBB, tubulin, beta class I; ULK1, unc-51 like autophagy activating kinase 1; UVRAG, UV radiation-resistance associated.
AB - ACTB, actin, beta; AKT, v-akt murine thymoma viral oncogene homolog; AMPK, 5'AMP-activated protein kinase; ANOVA, analysis of variance; ATG4B, autophagy-related 4B, cysteine peptidase; ATG5, autophagy-related 5; ATG7, autophagy-related 7; ATG12, autophagy-related 12; ATG13, autophagy-related 13; ATG14, autophagy-related 14; BCL2/ PPP1R50, B-cell CLL/lymphoma 2; BCL2L11/BIM, BCL2-like 11 (apoptosis facilitator); BECN1, Beclin 1, autophagy related; BNIP3, BCL2/adenovirus E1B 19 kDa interacting protein 3; BNIP3L/NIX, BCL2/adenovirus E1B 19 kDa interacting protein 3-like; DIA, diaphragm; EDL, extensor digitorium longus; EDTA, ethylenediaminetetraacetic acid; DTT, dithioreitol; FBXO32/ ATROGIN1, F-box protein 32; FOXO1, forkhead box O1; FOXO3, forkhead box O3; FOXO4, forkhead box O4; GABARAPL1, GABA(A) receptor-associated protein like 1; GP, gastrocnemius-plantaris; i.p., intraperitoneal; LAMP2A, lysosomal-associated membrane protein 2A; MAP1LC3B/LC3B, microtubule-associated protein 1 light chain 3 beta; MTORC1, mechanistic target of rapamycin complex 1; PARK2, parkinson protein 2, E3 ubiquitin protein ligase (parkin); PBS, phosphate-buffered saline; PIK3C3, phosphatidylinositol 3-kinase, catalytic subunit type 3; PMSF, phenylmethylsulfonyl fluoride; PVDF, polyvinylidene difluoride ; RB1CC1/FIP200, RB1-inducible coiled-coil 1; ROS, reactive oxygen species; RPS6, ribosomal protein S6; RPS6KB1, ribosomal protein S6 kinase, 70 kDa, polypeptide 1; SEM, standard error of the mean; SOD1, superoxide dismutase 1, soluble; SOL, soleus; SQSTM1/p62, sequestosome 1; TA, tibialis anterior; TRAF6/RNF85, TNF receptor-associated factor 6, E3 ubiquitin protein ligase; TUBB, tubulin, beta class I; ULK1, unc-51 like autophagy activating kinase 1; UVRAG, UV radiation-resistance associated.
KW - Autophagy
KW - Fiber-type composition
KW - Oxidative capacity
KW - Skeletal muscles
KW - Starvation
UR - http://www.scopus.com/inward/record.url?scp=84885640165&partnerID=8YFLogxK
U2 - 10.4161/auto.25955
DO - 10.4161/auto.25955
M3 - Article
C2 - 23955121
AN - SCOPUS:84885640165
SN - 1554-8627
VL - 9
SP - 1604
EP - 1620
JO - Autophagy
JF - Autophagy
IS - 10
ER -