Automated radiosynthesis of [11C]morphine for clinical investigation

Jinda Fan, Konrad Meissner, Gregory G. Gaehle, Shihong Li, Evan D. Kharasch, Robert H. Mach, Zhude Tu

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


To meet a multiple-dose clinical evaluation of the P-gp modulation of [11C]morphine delivery into the human brain, radiosynthesis of [11C]morphine was accomplished on an automated system by N-methylation of normorphine with [11C]CH3I. A methodology employing optimized solid phase extraction of the HPLC eluent was developed. Radiosynthesis took 45min with a radiochemical yield ranging from 45% to 50% and specific activity ranging from 20 to 26Ci/γmol (decay corrected to end-of-bombardment); radiochemical and chemical purities were >95% (n=28).

Original languageEnglish
Pages (from-to)431-435
Number of pages5
JournalApplied Radiation and Isotopes
Issue number2
StatePublished - Feb 2011


  • Automated radiosynthesis
  • Positron emission tomography
  • [C]morphine


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