Automated radiosynthesis of [11C]morphine for clinical investigation

Jinda Fan, Konrad Meissner, Gregory G. Gaehle, Shihong Li, Evan D. Kharasch, Robert H. Mach, Zhude Tu

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

To meet a multiple-dose clinical evaluation of the P-gp modulation of [11C]morphine delivery into the human brain, radiosynthesis of [11C]morphine was accomplished on an automated system by N-methylation of normorphine with [11C]CH3I. A methodology employing optimized solid phase extraction of the HPLC eluent was developed. Radiosynthesis took 45min with a radiochemical yield ranging from 45% to 50% and specific activity ranging from 20 to 26Ci/γmol (decay corrected to end-of-bombardment); radiochemical and chemical purities were >95% (n=28).

Original languageEnglish
Pages (from-to)431-435
Number of pages5
JournalApplied Radiation and Isotopes
Volume69
Issue number2
DOIs
StatePublished - Feb 1 2011

Keywords

  • Automated radiosynthesis
  • Positron emission tomography
  • [C]morphine

Fingerprint Dive into the research topics of 'Automated radiosynthesis of [<sup>11</sup>C]morphine for clinical investigation'. Together they form a unique fingerprint.

  • Cite this

    Fan, J., Meissner, K., Gaehle, G. G., Li, S., Kharasch, E. D., Mach, R. H., & Tu, Z. (2011). Automated radiosynthesis of [11C]morphine for clinical investigation. Applied Radiation and Isotopes, 69(2), 431-435. https://doi.org/10.1016/j.apradiso.2010.11.003