Automated production of [18F]VAT suitable for clinical PET study of vesicular acetylcholine transporter

Xuyi Yue; Christopher Bognar; Xiang Zhang; Gregory G. Gaehle; Stephen M. Moerlein; Joel S. Perlmutter; Zhude Tu

doi:10.1016/j.apradiso.2015.09.010

Automated production of [¹⁸F]VAT suitable for clinical PET study of vesicular acetylcholine transporter

Xuyi Yue
, Christopher Bognar
, Xiang Zhang
, Gregory G. Gaehle
, Stephen M. Moerlein
, Joel S. Perlmutter
, Zhude Tu

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Automated production of a promising radiopharmaceutical (-)-(1-(8-(2-[¹⁸F]fluoroethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-piperidin-4-yl)(4-fluorophenyl)methanone ([¹⁸F]VAT) for the vesicular acetylcholine transporter(VAChT) was achieved using a two-step procedure in a current Good Manufacturing Practices fashion. The production of [¹⁸F]VAT was accomplished in approximately 140min, with radiochemical yield of ~15.0% (decay corrected), specific activity>111GBq/μmol, radiochemical purity>99% and mass of VAT ~3.4μg/batch (n>10). The radiopharmaceutical product meets all quality control criteria for human use, and is suitable for clinical PET studies of VAChT.

Original language	English
Pages (from-to)	40-46
Number of pages	7
Journal	Applied Radiation and Isotopes
Volume	107
DOIs	https://doi.org/10.1016/j.apradiso.2015.09.010
State	Published - Jan 1 2016

Keywords

Automation
Clinical studies
Fluorine-18
Positron emission tomography
Vesicular acetylcholine transporter

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10.1016/j.apradiso.2015.09.010

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@article{b82c85c10c254ee289f22e0daf5be95d,

title = "Automated production of [18F]VAT suitable for clinical PET study of vesicular acetylcholine transporter",

abstract = "Automated production of a promising radiopharmaceutical (-)-(1-(8-(2-[18F]fluoroethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-piperidin-4-yl)(4-fluorophenyl)methanone ([18F]VAT) for the vesicular acetylcholine transporter(VAChT) was achieved using a two-step procedure in a current Good Manufacturing Practices fashion. The production of [18F]VAT was accomplished in approximately 140min, with radiochemical yield of \textasciitilde{}15.0\% (decay corrected), specific activity>111GBq/μmol, radiochemical purity>99\% and mass of VAT \textasciitilde{}3.4μg/batch (n>10). The radiopharmaceutical product meets all quality control criteria for human use, and is suitable for clinical PET studies of VAChT.",

keywords = "Automation, Clinical studies, Fluorine-18, Positron emission tomography, Vesicular acetylcholine transporter",

author = "Xuyi Yue and Christopher Bognar and Xiang Zhang and Gaehle, \{Gregory G.\} and Moerlein, \{Stephen M.\} and Perlmutter, \{Joel S.\} and Zhude Tu",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Ltd.",

year = "2016",

month = jan,

day = "1",

doi = "10.1016/j.apradiso.2015.09.010",

language = "English",

volume = "107",

pages = "40--46",

journal = "Applied Radiation and Isotopes",

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TY - JOUR

T1 - Automated production of [18F]VAT suitable for clinical PET study of vesicular acetylcholine transporter

AU - Yue, Xuyi

AU - Bognar, Christopher

AU - Zhang, Xiang

AU - Gaehle, Gregory G.

AU - Moerlein, Stephen M.

AU - Perlmutter, Joel S.

AU - Tu, Zhude

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Automated production of a promising radiopharmaceutical (-)-(1-(8-(2-[18F]fluoroethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-piperidin-4-yl)(4-fluorophenyl)methanone ([18F]VAT) for the vesicular acetylcholine transporter(VAChT) was achieved using a two-step procedure in a current Good Manufacturing Practices fashion. The production of [18F]VAT was accomplished in approximately 140min, with radiochemical yield of ~15.0% (decay corrected), specific activity>111GBq/μmol, radiochemical purity>99% and mass of VAT ~3.4μg/batch (n>10). The radiopharmaceutical product meets all quality control criteria for human use, and is suitable for clinical PET studies of VAChT.

AB - Automated production of a promising radiopharmaceutical (-)-(1-(8-(2-[18F]fluoroethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-piperidin-4-yl)(4-fluorophenyl)methanone ([18F]VAT) for the vesicular acetylcholine transporter(VAChT) was achieved using a two-step procedure in a current Good Manufacturing Practices fashion. The production of [18F]VAT was accomplished in approximately 140min, with radiochemical yield of ~15.0% (decay corrected), specific activity>111GBq/μmol, radiochemical purity>99% and mass of VAT ~3.4μg/batch (n>10). The radiopharmaceutical product meets all quality control criteria for human use, and is suitable for clinical PET studies of VAChT.

KW - Automation

KW - Clinical studies

KW - Fluorine-18

KW - Positron emission tomography

KW - Vesicular acetylcholine transporter

UR - https://www.scopus.com/pages/publications/84942284406

U2 - 10.1016/j.apradiso.2015.09.010

DO - 10.1016/j.apradiso.2015.09.010

M3 - Article

C2 - 26408913

AN - SCOPUS:84942284406

SN - 0969-8043

VL - 107

SP - 40

EP - 46

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

ER -

Automated production of [¹⁸F]VAT suitable for clinical PET study of vesicular acetylcholine transporter

Abstract

Keywords

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