Automated production of [18F]VAT suitable for clinical PET study of vesicular acetylcholine transporter

Xuyi Yue, Christopher Bognar, Xiang Zhang, Gregory G. Gaehle, Stephen M. Moerlein, Joel S. Perlmutter, Zhude Tu

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

Automated production of a promising radiopharmaceutical (-)-(1-(8-(2-[18F]fluoroethoxy)-3-hydroxy-1,2,3,4-tetrahydronaphthalen-2-yl)-piperidin-4-yl)(4-fluorophenyl)methanone ([18F]VAT) for the vesicular acetylcholine transporter(VAChT) was achieved using a two-step procedure in a current Good Manufacturing Practices fashion. The production of [18F]VAT was accomplished in approximately 140min, with radiochemical yield of ~15.0% (decay corrected), specific activity>111GBq/μmol, radiochemical purity>99% and mass of VAT ~3.4μg/batch (n>10). The radiopharmaceutical product meets all quality control criteria for human use, and is suitable for clinical PET studies of VAChT.

Original languageEnglish
Pages (from-to)40-46
Number of pages7
JournalApplied Radiation and Isotopes
Volume107
DOIs
StatePublished - Jan 1 2016

Keywords

  • Automation
  • Clinical studies
  • Fluorine-18
  • Positron emission tomography
  • Vesicular acetylcholine transporter

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