TY - JOUR
T1 - Automated placement of retinal laser lesions in vivo
AU - Barrett, Steven F.
AU - Wright, Cameron H.G.
AU - Jerath, Maya R.
AU - Stephen Lewis, R.
AU - Dillard, Bryan C.
AU - Grady Rylander, H.
AU - Welch, Ashley J.
N1 - Funding Information:
United States Air Force Academy, Department ofElectrical Engineering, USAF Academy, CO 80840 (SFB, RSL, BCD) University of Texas at Austin, Biomedical Engineering Program, Anstin, TX 78712 (CHGW, HGR, AJW) Radiobiology Laboratories, Dartmouth Hitchcock Medical Center, Dartmouth College, Lebanon, NIH 03756 (MRJ)
Funding Information:
This work was supported in part by the Texas Coordinating Board; the Office of Naval Research under grant N00014-91-J-1564; Frank J. Seiler Research Laboratory, USAF Academy, CO; Armstrong Laboratory, Brooks AFB, TX; and Phillips Laboratory, Kirtland AFB, NM.
Publisher Copyright:
© 1995 SPIE. All rights reserved.
PY - 1995/3/3
Y1 - 1995/3/3
N2 - Researchers at the University of Texas at Austin's Biomedical Engineering Laser Laboratory investigating the medical applications of lasers have worked toward the development of a retinal robotic laser system. The overall goal of this ongoing project is to precisely place and control the depth of laser lesions for the treatment of various retinal diseases such as diabetic retinopathy and retinal tears. Researchers at the USAF Academy's Department of Electrical Engineering and and the Optical Radiation Division of Armstrong Laboratory have also become involved with this research due to similar related interests. Separate low speed prototype subsystems have been developed to conirol lesion depth using lesion reflectance feedback parameters and lesion placement using retinal vessels as tracking landmarks. Both subsystems have been successfully demonstrated in vivo on pigmented rabbits using an argon continuous wave laser. Work is ongoing to build a prototype system to simultaneously control lesion depth arid placement. Following the dual-use concept, this system is being adapted for clinical use as a retinal treatment system as well as a research tool for military laser-Tissue interaction studies. Specifically, the system is being adapted for use with an ultra-short pulse laser system at Armstrong Laboratory and Frank J. Seiler Research Laboratory to study the effects of ultra-short laser pulses on the human retina. The instrumentation aspects of the prototype subsystems were presented at SPIE Conference 1877 in January 1993. Since then our efforts have concentrated on combining the lesion depth control subsystem and the lesion placement subsystem into a single prototype capable of simultaneously controlling both parameters. We have designated this combined system CALOSOS for Computer Aided Laser Optics System for Ophthalmic Surgery. We have also investigated methods to improve system response time. Use of high speed non-standard frame rate CCD cameras and high speed frame grabbers hosted on personal computers featuring the 32 bit, 33 MHz PCI bus have been investigated. Design details of an initial CALOSOS prototype design is provided in SPifi Conference proceedings 2396B-32 (Biomedical Optics Conference, Clinical Laser Delivery and Robotics Session). This paper will review in vivo testing to date and detail planned system upgrades.
AB - Researchers at the University of Texas at Austin's Biomedical Engineering Laser Laboratory investigating the medical applications of lasers have worked toward the development of a retinal robotic laser system. The overall goal of this ongoing project is to precisely place and control the depth of laser lesions for the treatment of various retinal diseases such as diabetic retinopathy and retinal tears. Researchers at the USAF Academy's Department of Electrical Engineering and and the Optical Radiation Division of Armstrong Laboratory have also become involved with this research due to similar related interests. Separate low speed prototype subsystems have been developed to conirol lesion depth using lesion reflectance feedback parameters and lesion placement using retinal vessels as tracking landmarks. Both subsystems have been successfully demonstrated in vivo on pigmented rabbits using an argon continuous wave laser. Work is ongoing to build a prototype system to simultaneously control lesion depth arid placement. Following the dual-use concept, this system is being adapted for clinical use as a retinal treatment system as well as a research tool for military laser-Tissue interaction studies. Specifically, the system is being adapted for use with an ultra-short pulse laser system at Armstrong Laboratory and Frank J. Seiler Research Laboratory to study the effects of ultra-short laser pulses on the human retina. The instrumentation aspects of the prototype subsystems were presented at SPIE Conference 1877 in January 1993. Since then our efforts have concentrated on combining the lesion depth control subsystem and the lesion placement subsystem into a single prototype capable of simultaneously controlling both parameters. We have designated this combined system CALOSOS for Computer Aided Laser Optics System for Ophthalmic Surgery. We have also investigated methods to improve system response time. Use of high speed non-standard frame rate CCD cameras and high speed frame grabbers hosted on personal computers featuring the 32 bit, 33 MHz PCI bus have been investigated. Design details of an initial CALOSOS prototype design is provided in SPifi Conference proceedings 2396B-32 (Biomedical Optics Conference, Clinical Laser Delivery and Robotics Session). This paper will review in vivo testing to date and detail planned system upgrades.
UR - http://www.scopus.com/inward/record.url?scp=85076799355&partnerID=8YFLogxK
U2 - 10.1117/12.205019
DO - 10.1117/12.205019
M3 - Conference article
AN - SCOPUS:85076799355
SN - 0277-786X
VL - 2374
SP - 293
EP - 301
JO - Proceedings of SPIE - The International Society for Optical Engineering
JF - Proceedings of SPIE - The International Society for Optical Engineering
T2 - Novel Applications of Lasers and Pulsed Power 1995
Y2 - 1 February 1995 through 28 February 1995
ER -