@article{f26109a8337948a88fa8dd045e08ded0,
title = "Autologous transplantation as consolidation for high risk aggressive T-cell non-Hodgkin lymphoma: a SWOG 9704 intergroup trial subgroup analysis",
abstract = "Phase II data suggest a benefit to autotransplantation for aggressive T-cell non-Hodgkin lymphoma (T-NHL) in first remission; randomized trials have yet to validate this. We performed a retrospective analysis of aggressive T-NHL patients in the intergroup randomized consolidative autotransplant trial (SWOG 9704). Of the 370 enrolled, 40 had T-NHL: 12 were not randomized due to ineligibility (n = 1), choice (n = 2), or progression (n = 9), leaving 13 randomized to control and 15 to autologous stem cell transplantation (ASCT). Two ASCT patients refused transplant and one failed mobilization. The 5-year landmark PFS/OS estimates for ASCT vs. control groups were 40% vs. 38% (p =.56), and 40% vs. 45% (p =.98), respectively. No difference was seen based on IPI, or histologic subtype. Only 1/7 receiving BCNU-based therapy survived vs. 4/5 receiving TBI. Aggressive T-NHL autotransplanted in first remission did not appear to benefit from consolidative ASCT. This and the 30% who dropped out pre-randomization mostly to progression, suggests that improved induction regimens be developed.",
keywords = "T-NHL treatment, consolidative autotransplant, high-risk T-NHL",
author = "Zeina Al-Mansour and Hongli Li and Cook, {James R.} and Constine, {Louis S.} and Stephen Couban and Stewart, {Douglas A.} and Shea, {Thomas C.} and Pierluigi Porcu and Winter, {Jane N.} and Kahl, {Brad S.} and Smith, {Sonali M.} and Marcellus, {Deborah C.} and Barton, {Kevin P.} and Mills, {Glenn M.} and Michael LeBlanc and Rimsza, {Lisa M.} and Forman, {Stephen J.} and Leonard, {John P.} and Fisher, {Richard I.} and Friedberg, {Jonathan W.} and Stiff, {Patrick J.}",
note = "Funding Information: Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under the following award numbers: CA180888, CA180819, CA180820, CA180821, CA180863, CCSRI #021039; legacy grants CA46282, CA04919, CA11083, CA58658, CA46368, CA13612; and in part by Bristol-Myers Squibb. The content is solely the responsibility of the authors and does not necessarily represent the official views of either the National Institutes of Health or Bristol-Myers Squibb. Publisher Copyright: {\textcopyright} 2019, {\textcopyright} 2019 Informa UK Limited, trading as Taylor & Francis Group.",
year = "2019",
month = jul,
day = "3",
doi = "10.1080/10428194.2018.1563691",
language = "English",
volume = "60",
pages = "1934--1941",
journal = "Leukemia and Lymphoma",
issn = "1042-8194",
number = "8",
}