Autoimmune pancerebellitis associated with pembrolizumab therapy

Jeffrey R. Vitt, Collin Kreple, Nausheen Mahmood, Elliot Dickerson, Giselle Y. Lopez, Megan B. Richie

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Checkpoint proteins reduce immune-mediated responses to promote self-tolerance and prevent autoimmunity. Programmed cell death protein 1 (PD-1) is a checkpoint receptor protein expressed on leukocytes that inactivates T cell-mediated immunity when bound to ligand PDL1. Certain tumors can escape immune-mediated destruction by expressing high concentrations of PD-L1, evading host surveillance.1 PD-1 pathway inhibitors effectively treat multiple malignancies including melanoma, non-small cell lung cancer, and squamous cell carcinoma.2 However, there is increasing recognition of immune-related adverse events (irAE) associated with checkpoint inhibitor therapy due to dysregulated immune system activation.1 We report immune-mediated cerebellitis following pembrolizumab.

Original languageEnglish
Pages (from-to)91-93
Number of pages3
JournalNeurology
Volume91
Issue number2
DOIs
StatePublished - 2018

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