Autoimmune gld mutation uncouples suicide and cytokine/proliferation pathways in activated, mature T cells

John H. Russell, Ruduan Wang

Research output: Contribution to journalArticlepeer-review

138 Scopus citations

Abstract

Antigen receptor‐directed suicide plays an important role in the elimination of potentially autoaggressive immature T cells during thymic differentiation. Here we demonstrate evidence for a second pathway of receptor‐directed suicide in mature T cells that is missing in a mutant strain gld of mice with an “autoimmune” lymphoproliferative syndrome. The defect is evident within the gld activated T cell and does not require the presence of an antigen‐presenting cell for its expression. Receptor‐driven suicide is intact in immature T cells of animals with this mutation. These results support the significance of receptor‐directed suicide in the mature T cell compartment and suggest that the immune system may use three independent pathways for regulating programmed cell death in shaping and controlling the immune response.

Original languageEnglish
Pages (from-to)2379-2382
Number of pages4
JournalEuropean Journal of Immunology
Volume23
Issue number9
DOIs
StatePublished - Sep 1993

Keywords

  • Autoimmunity/Programmed cell death/Inflammation/Peripheral tolerance

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