TY - JOUR
T1 - Aurora-A phosphorylates, activates, and relocalizes the small GTPase Ra1A
AU - Lim, Kian Huat
AU - Brady, Donita C.
AU - Kashatus, David F.
AU - Ancrile, Brooke B.
AU - Der, Channing J.
AU - Cox, Adrienne D.
AU - Counter, Christopher M.
PY - 2010/1
Y1 - 2010/1
N2 - The small GTPase Ras, which transmits extracellular signals to the cell, and the kinase Aurora-A, which promotes proper mitosis, can both be inappropriately activated in human tumors. Here, we show that Aurora-A in conjunction with oncogenic Ras enhances transformed cell growth. Furthermore, such transformation and in some cases also tumorigenesis depend upon S194 of RalA, a known Aurora-A phosphorylation site. Aurora-A promotes not only RalA activation but also translocation from the plasma membrane and activation of the effector protein RalBP1. Taken together, these data suggest that Aurora-A may converge upon oncogenic Ras signaling through RalA.
AB - The small GTPase Ras, which transmits extracellular signals to the cell, and the kinase Aurora-A, which promotes proper mitosis, can both be inappropriately activated in human tumors. Here, we show that Aurora-A in conjunction with oncogenic Ras enhances transformed cell growth. Furthermore, such transformation and in some cases also tumorigenesis depend upon S194 of RalA, a known Aurora-A phosphorylation site. Aurora-A promotes not only RalA activation but also translocation from the plasma membrane and activation of the effector protein RalBP1. Taken together, these data suggest that Aurora-A may converge upon oncogenic Ras signaling through RalA.
UR - https://www.scopus.com/pages/publications/73549119929
U2 - 10.1128/MCB.00916-08
DO - 10.1128/MCB.00916-08
M3 - Article
C2 - 19901077
AN - SCOPUS:73549119929
SN - 0270-7306
VL - 30
SP - 508
EP - 523
JO - Molecular and cellular biology
JF - Molecular and cellular biology
IS - 2
ER -