TY - JOUR
T1 - Augmentation of IgE-mediated release of histamine by 5-hydroxyeicosatetraenoic acid and 12-hydroxyeicosatetraenoic acid
AU - Stenson, William F.
AU - Parker, Charles W.
AU - Sullivan, Timothy J.
N1 - Funding Information:
assistance of in part by NIH
PY - 1980
Y1 - 1980
N2 - Highly purified rat mast cells converted 1.12% and 1.64% of exogenously added [1-14C]arachidonic acid to 5-OH-6,8,11,14 eicosatetraenoic acid (5-HETE) and 12-OH-5,8,10,14 eicosatetraenoic acid (12-HETE) respectively during a three minute incubation at 37°. Both 5-HETE and 12-HETE (1–10 μM) augmented the histamine release response to goat anti-rat IgE antibody (a reverse anaphylaxis system). These results indicate that mast cells synthesize 5-HETE and 12-HETE and that these molecules can enhance mediator release.
AB - Highly purified rat mast cells converted 1.12% and 1.64% of exogenously added [1-14C]arachidonic acid to 5-OH-6,8,11,14 eicosatetraenoic acid (5-HETE) and 12-OH-5,8,10,14 eicosatetraenoic acid (12-HETE) respectively during a three minute incubation at 37°. Both 5-HETE and 12-HETE (1–10 μM) augmented the histamine release response to goat anti-rat IgE antibody (a reverse anaphylaxis system). These results indicate that mast cells synthesize 5-HETE and 12-HETE and that these molecules can enhance mediator release.
UR - https://www.scopus.com/pages/publications/0019163705
U2 - 10.1016/0006-291X(80)90058-3
DO - 10.1016/0006-291X(80)90058-3
M3 - Article
C2 - 6159889
AN - SCOPUS:0019163705
VL - 96
SP - 1045
EP - 1052
JO - Topics in Catalysis
JF - Topics in Catalysis
IS - 3
ER -