Augmentation of IgE-mediated release of histamine by 5-hydroxyeicosatetraenoic acid and 12-hydroxyeicosatetraenoic acid

William F. Stenson, Charles W. Parker, Timothy J. Sullivan

Research output: Contribution to journalArticlepeer-review

40 Scopus citations

Abstract

Highly purified rat mast cells converted 1.12% and 1.64% of exogenously added [1-14C]arachidonic acid to 5-OH-6,8,11,14 eicosatetraenoic acid (5-HETE) and 12-OH-5,8,10,14 eicosatetraenoic acid (12-HETE) respectively during a three minute incubation at 37°. Both 5-HETE and 12-HETE (1–10 μM) augmented the histamine release response to goat anti-rat IgE antibody (a reverse anaphylaxis system). These results indicate that mast cells synthesize 5-HETE and 12-HETE and that these molecules can enhance mediator release.

Original languageEnglish
Pages (from-to)1045-1052
Number of pages8
JournalTopics in Catalysis
Volume96
Issue number3
DOIs
StatePublished - 1980

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