Atypical depression, atypical temperament and a differential antidepressant response to fluoxetine and nortriptyline

Peter R. Joyce, Roger T. Mulder, Janice M. McKenzie, Suzanne E. Luty, C. Robert Cloninger

    Research output: Contribution to journalArticlepeer-review

    33 Scopus citations

    Abstract

    We examined the personality characteristics of depressed patients with and without atypical depression. Of 195 depressed outpatients in a randomized treatment trial of fluoxetine or nortriptyline, 16 met DSA-IV criteria for atypical depression. We compared the personality traits and disorders in those with and without atypical depression. In atypical depression, fluoxetine was superior to nortriptyline. On the Temperament and Character Inventory, those with atypical depression had high attachment, low persistence, and high anticipatory anxiety. A temperament construct of these dimensions was associated with a differential antidepressant response, regardless of other atypical features. A temperament derived measure of "rejection sensitivity" defines a group of depressed patients with a differential antidepressant response, regardless of reversed vegetative symptoms.

    Original languageEnglish
    Pages (from-to)180-186
    Number of pages7
    JournalDepression and Anxiety
    Volume19
    Issue number3
    DOIs
    StatePublished - Jun 8 2004

    Keywords

    • Atypical depression
    • Rejection sensitivity
    • Temperament
    • Treatment response

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