Atherosclerotic neovasculature MR imaging with mixed manganese-gadolinium nanocolloids in hyperlipidemic rabbits

Kezheng Wang; Dipanjan Pan; Anne H. Schmieder; Angana Senpan; Shelton D. Caruthers; Grace Cui; John S. Allen; Huiying Zhang; Baozhong Shen; Gregory M. Lanza

doi:10.1016/j.nano.2014.12.008

Atherosclerotic neovasculature MR imaging with mixed manganese-gadolinium nanocolloids in hyperlipidemic rabbits

Kezheng Wang, Dipanjan Pan, Anne H. Schmieder, Angana Senpan, Shelton D. Caruthers, Grace Cui, John S. Allen, Huiying Zhang, Baozhong Shen, Gregory M. Lanza

Research output: Contribution to journal › Article › peer-review

11 Scopus citations

Abstract

A high r1 relaxivity manganese-gadolinium nanocolloid (α_vβ₃-MnOL-Gd NC) was developed and effectively detected atherosclerotic angiogenesis in rabbits fed cholesterol-rich diets for 12months using a clinical MRI scanner (3T). 3D mapping of neovasculature signal intensity revealed the spatial coherence and intensity of plaque angiogenic expansion, which may, with other high risk MR bioindicators, help identify high-risk patients with moderate (40% to 60%) vascular stenosis. Microscopy confirmed the predominant media and plaque distribution of fluorescent α_vβ₃-MnOL-Gd NC, mirroring the MR data. An expected close spatial association of α_vβ₃-integrin neovasculature and macrophages was noted, particularly within plaque shoulder regions. Manganese oleate bioelimination occurred via the biliary system into feces. Gd-DOTA was eliminated through the bile-fecal and renal excretion routes. α_vβ₃-MnOL-Gd NC offers an effective vehicle for T1w neovascular imaging in atherosclerosis.

Original language	English
Pages (from-to)	569-578
Number of pages	10
Journal	Nanomedicine: Nanotechnology, Biology, and Medicine
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/j.nano.2014.12.008
State	Published - 2015

Keywords

Angiogenesis
Atherosclerosis
Contrast media
MRI
Molecular imaging
Nanotechnology

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title = "Atherosclerotic neovasculature MR imaging with mixed manganese-gadolinium nanocolloids in hyperlipidemic rabbits",

abstract = "A high r1 relaxivity manganese-gadolinium nanocolloid (αvβ3-MnOL-Gd NC) was developed and effectively detected atherosclerotic angiogenesis in rabbits fed cholesterol-rich diets for 12months using a clinical MRI scanner (3T). 3D mapping of neovasculature signal intensity revealed the spatial coherence and intensity of plaque angiogenic expansion, which may, with other high risk MR bioindicators, help identify high-risk patients with moderate (40% to 60%) vascular stenosis. Microscopy confirmed the predominant media and plaque distribution of fluorescent αvβ3-MnOL-Gd NC, mirroring the MR data. An expected close spatial association of αvβ3-integrin neovasculature and macrophages was noted, particularly within plaque shoulder regions. Manganese oleate bioelimination occurred via the biliary system into feces. Gd-DOTA was eliminated through the bile-fecal and renal excretion routes. αvβ3-MnOL-Gd NC offers an effective vehicle for T1w neovascular imaging in atherosclerosis.",

keywords = "Angiogenesis, Atherosclerosis, Contrast media, MRI, Molecular imaging, Nanotechnology",

author = "Kezheng Wang and Dipanjan Pan and Schmieder, {Anne H.} and Angana Senpan and Caruthers, {Shelton D.} and Grace Cui and Allen, {John S.} and Huiying Zhang and Baozhong Shen and Lanza, {Gregory M.}",

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year = "2015",

doi = "10.1016/j.nano.2014.12.008",

language = "English",

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AU - Wang, Kezheng

AU - Pan, Dipanjan

AU - Schmieder, Anne H.

AU - Senpan, Angana

AU - Caruthers, Shelton D.

AU - Cui, Grace

AU - Allen, John S.

AU - Zhang, Huiying

AU - Shen, Baozhong

AU - Lanza, Gregory M.

PY - 2015

Y1 - 2015

N2 - A high r1 relaxivity manganese-gadolinium nanocolloid (αvβ3-MnOL-Gd NC) was developed and effectively detected atherosclerotic angiogenesis in rabbits fed cholesterol-rich diets for 12months using a clinical MRI scanner (3T). 3D mapping of neovasculature signal intensity revealed the spatial coherence and intensity of plaque angiogenic expansion, which may, with other high risk MR bioindicators, help identify high-risk patients with moderate (40% to 60%) vascular stenosis. Microscopy confirmed the predominant media and plaque distribution of fluorescent αvβ3-MnOL-Gd NC, mirroring the MR data. An expected close spatial association of αvβ3-integrin neovasculature and macrophages was noted, particularly within plaque shoulder regions. Manganese oleate bioelimination occurred via the biliary system into feces. Gd-DOTA was eliminated through the bile-fecal and renal excretion routes. αvβ3-MnOL-Gd NC offers an effective vehicle for T1w neovascular imaging in atherosclerosis.

AB - A high r1 relaxivity manganese-gadolinium nanocolloid (αvβ3-MnOL-Gd NC) was developed and effectively detected atherosclerotic angiogenesis in rabbits fed cholesterol-rich diets for 12months using a clinical MRI scanner (3T). 3D mapping of neovasculature signal intensity revealed the spatial coherence and intensity of plaque angiogenic expansion, which may, with other high risk MR bioindicators, help identify high-risk patients with moderate (40% to 60%) vascular stenosis. Microscopy confirmed the predominant media and plaque distribution of fluorescent αvβ3-MnOL-Gd NC, mirroring the MR data. An expected close spatial association of αvβ3-integrin neovasculature and macrophages was noted, particularly within plaque shoulder regions. Manganese oleate bioelimination occurred via the biliary system into feces. Gd-DOTA was eliminated through the bile-fecal and renal excretion routes. αvβ3-MnOL-Gd NC offers an effective vehicle for T1w neovascular imaging in atherosclerosis.

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KW - Atherosclerosis

KW - Contrast media

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KW - Molecular imaging

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Atherosclerotic neovasculature MR imaging with mixed manganese-gadolinium nanocolloids in hyperlipidemic rabbits

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