@article{50fc757c567c42b48905d3cb53e5949c,
title = "Atherosclerotic neovasculature MR imaging with mixed manganese-gadolinium nanocolloids in hyperlipidemic rabbits",
abstract = "A high r1 relaxivity manganese-gadolinium nanocolloid (αvβ3-MnOL-Gd NC) was developed and effectively detected atherosclerotic angiogenesis in rabbits fed cholesterol-rich diets for 12months using a clinical MRI scanner (3T). 3D mapping of neovasculature signal intensity revealed the spatial coherence and intensity of plaque angiogenic expansion, which may, with other high risk MR bioindicators, help identify high-risk patients with moderate (40% to 60%) vascular stenosis. Microscopy confirmed the predominant media and plaque distribution of fluorescent αvβ3-MnOL-Gd NC, mirroring the MR data. An expected close spatial association of αvβ3-integrin neovasculature and macrophages was noted, particularly within plaque shoulder regions. Manganese oleate bioelimination occurred via the biliary system into feces. Gd-DOTA was eliminated through the bile-fecal and renal excretion routes. αvβ3-MnOL-Gd NC offers an effective vehicle for T1w neovascular imaging in atherosclerosis.",
keywords = "Angiogenesis, Atherosclerosis, Contrast media, MRI, Molecular imaging, Nanotechnology",
author = "Kezheng Wang and Dipanjan Pan and Schmieder, {Anne H.} and Angana Senpan and Caruthers, {Shelton D.} and Grace Cui and Allen, {John S.} and Huiying Zhang and Baozhong Shen and Lanza, {Gregory M.}",
note = "Funding Information: Acknowledgement: The support derived in part from the National Institutes of Health under grant numbers HL112518 (GML), HL113392 (GML/EMW), CA100623 (GML), CA154737 (GML), SBIR (HHSN268201400042CAW/GML), and the Barnes-Jewish Hospital Charitable Foundation is greatly appreciated. This research was also supported in part by the National Natural Science Foundation of China ( 81130028,31210103913 ) (BS), the Key Grant Project of Heilongjiang Province ( GA12C302 ) (BS), the Ph.D. Programs Foundation of Ministry of Education of China ( 201123071100203 ) (BS), and the Key Laboratory of Molecular Imaging Foundation (College of Heilongjiang Province) (BS), the National Natural Science Foundation for Young Scholars of China ( 81101086 ) (KW), China Postdoctoral Science Foundation ( 20100471020 ) (KW), China Postdoctoral Special Science Foundation ( 2012T50375 ) (KW) and Scientific Research Grant of Heilongjiang Province Natural Science Foundation for Returned Chinese Scholars ( LC201436 ) (KW). The authors gratefully acknowledge the scientific input of Drs. Christine Pham and Dennis Hourcade Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",
year = "2015",
doi = "10.1016/j.nano.2014.12.008",
language = "English",
volume = "11",
pages = "569--578",
journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",
issn = "1549-9634",
number = "3",
}