TY - JOUR
T1 - Atherosclerosis and transit of HDL through the lymphatic vasculature.
AU - Martel, Catherine
AU - Randolph, Gwendalyn J.
PY - 2013
Y1 - 2013
N2 - Key components of atherosclerotic plaque known to drive disease progression are macrophages and cholesterol. It has been widely understood, and bolstered by recent evidence, that the efflux of cholesterol from macrophage foam cells quells disease progression or even to promote regression. Following macrophage cholesterol efflux, cholesterol loaded onto HDL must be removed from the plaque environment. Here, we focus on recent evidence that the lymphatic vasculature is critical for the removal of cholesterol, likely as a component of HDL, from tissues including skin and the artery wall. We discuss the possibility that progression of atherosclerosis might in part be linked to sluggish removal of cholesterol from the plaque.
AB - Key components of atherosclerotic plaque known to drive disease progression are macrophages and cholesterol. It has been widely understood, and bolstered by recent evidence, that the efflux of cholesterol from macrophage foam cells quells disease progression or even to promote regression. Following macrophage cholesterol efflux, cholesterol loaded onto HDL must be removed from the plaque environment. Here, we focus on recent evidence that the lymphatic vasculature is critical for the removal of cholesterol, likely as a component of HDL, from tissues including skin and the artery wall. We discuss the possibility that progression of atherosclerosis might in part be linked to sluggish removal of cholesterol from the plaque.
UR - http://www.scopus.com/inward/record.url?scp=84897356615&partnerID=8YFLogxK
U2 - 10.1007/s11883-013-0354-4
DO - 10.1007/s11883-013-0354-4
M3 - Review article
C2 - 23912686
AN - SCOPUS:84897356615
SN - 1523-3804
VL - 15
SP - 354
JO - Current Atherosclerosis Reports
JF - Current Atherosclerosis Reports
IS - 9
ER -