ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors

Richard S. Marshall; Zhihua Hua; Sujina Mali; Fionn McLoughlin; Richard D. Vierstra

doi:10.1016/j.cell.2019.02.009

ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors

Richard S. Marshall, Zhihua Hua, Sujina Mali, Fionn McLoughlin, Richard D. Vierstra

Research output: Contribution to journal › Article › peer-review

206 Scopus citations

Abstract

Across organisms, the key autophagy protein ATG8/LC3 binds a group of proteins on a site distinct from its classical interacting region, raising the possibility of dual binding interactions and identifying an array of previously unknown selective autophagic adaptors and receptors, including some involved in human disease.

Original language	English
Pages (from-to)	766-781.e24
Journal	Cell
Volume	177
Issue number	3
DOIs	https://doi.org/10.1016/j.cell.2019.02.009
State	Published - Apr 18 2019

Keywords

AIM
ATG8
ATG8-interacting motif
Arabidopsis
CDC48/p97
LC3-interacting region
LDS
LIR
LIR/AIM-docking site
UDS
UIM
UIM-docking site
autophagy
ubiquitin-interacting motif
yeast

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10.1016/j.cell.2019.02.009

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title = "ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors",

abstract = "Across organisms, the key autophagy protein ATG8/LC3 binds a group of proteins on a site distinct from its classical interacting region, raising the possibility of dual binding interactions and identifying an array of previously unknown selective autophagic adaptors and receptors, including some involved in human disease.",

keywords = "AIM, ATG8, ATG8-interacting motif, Arabidopsis, CDC48/p97, LC3-interacting region, LDS, LIR, LIR/AIM-docking site, UDS, UIM, UIM-docking site, autophagy, ubiquitin-interacting motif, yeast",

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AU - Marshall, Richard S.

AU - Hua, Zhihua

AU - Mali, Sujina

AU - McLoughlin, Fionn

AU - Vierstra, Richard D.

PY - 2019/4/18

Y1 - 2019/4/18

N2 - Across organisms, the key autophagy protein ATG8/LC3 binds a group of proteins on a site distinct from its classical interacting region, raising the possibility of dual binding interactions and identifying an array of previously unknown selective autophagic adaptors and receptors, including some involved in human disease.

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KW - ATG8

KW - ATG8-interacting motif

KW - Arabidopsis

KW - CDC48/p97

KW - LC3-interacting region

KW - LDS

KW - LIR

KW - LIR/AIM-docking site

KW - UDS

KW - UIM

KW - UIM-docking site

KW - autophagy

KW - ubiquitin-interacting motif

KW - yeast

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DO - 10.1016/j.cell.2019.02.009

M3 - Article

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SN - 0092-8674

VL - 177

SP - 766-781.e24

JO - Cell

JF - Cell

IS - 3

ER -

ATG8-Binding UIM Proteins Define a New Class of Autophagy Adaptors and Receptors

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Keywords

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