Astrocytes modulate the polarization of CD4+ T cells to Th1 cells

Eléonore Beurel, Laurie E. Harrington, William Buchser, Vance Lemmon, Richard S. Jope

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

T-cell characteristics are dynamic and influenced by multiple factors. To test whether cells and the environment in the central nervous system (CNS) can influence T-cells, we tested if culturing mouse CD4+ T-cells on mouse primary astrocytes, compared with standard feeder cells, modified T-cell polarization to Th1 and Treg subtypes. Astrocytes supported the production of Th1 cells and Tregs, which was diminished by inflammatory activation of astrocytes, and glutamate accumulation that may result from impaired glutamate uptake by astrocytes strongly promoted Th1 production. These results demonstrate that astrocytes and the environment in the CNS have the capacity to regulate T-cell characteristics.

Original languageEnglish
Article numbere86257
JournalPloS one
Volume9
Issue number1
DOIs
StatePublished - Jan 28 2014

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