TY - JOUR
T1 - Astrocyte interleukin-3 preps microglia
AU - Klein, Robyn S.
N1 - Funding Information:
This work was supported by grants from the National Institutes of Health ( R35NS122310 , R01NS116788 ) and the National Multiple Sclerosis Society ( RG 1801-29766 ).
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/11
Y1 - 2021/11
N2 - Brain β-amyloid (Aβ) deposition is a biomarker for Alzheimer's disease (AD) and other dementias, in which Aβ amounts correlate with disease burden. McAlpine et al. reveal that astrocyte expression or administration of interleukin (IL)-3 in the context of aggregated Aβ endows microglia with enhanced capability to cluster and clear Aβ oligomers.
AB - Brain β-amyloid (Aβ) deposition is a biomarker for Alzheimer's disease (AD) and other dementias, in which Aβ amounts correlate with disease burden. McAlpine et al. reveal that astrocyte expression or administration of interleukin (IL)-3 in the context of aggregated Aβ endows microglia with enhanced capability to cluster and clear Aβ oligomers.
UR - http://www.scopus.com/inward/record.url?scp=85117211503&partnerID=8YFLogxK
U2 - 10.1016/j.it.2021.09.008
DO - 10.1016/j.it.2021.09.008
M3 - Short survey
C2 - 34657802
AN - SCOPUS:85117211503
SN - 1471-4906
VL - 42
SP - 937
EP - 939
JO - Trends in Immunology
JF - Trends in Immunology
IS - 11
ER -