TY - JOUR
T1 - Associations of NADPH oxidase-related genes with blood pressure changes and incident hypertension
T2 - The GenSalt Study
AU - Li, Hongfan
AU - Han, Xikun
AU - Hu, Zunsong
AU - Huang, Jianfeng
AU - Chen, Jing
AU - Hixson, James E.
AU - Rao, Dabeeru C.
AU - He, Jiang
AU - Gu, Dongfeng
AU - Chen, Shufeng
N1 - Funding Information:
Acknowledgements This study is supported by the National Natural Science Foundation of China (81570386, 91439202, 91643208 and 81600332) and the CAMS Innovation Fund for Medical Sciences (grants no. 2017-I2M-1–004 and 2016-I2M-2–001). The GenSalt study is supported by a cooperative agreement project grant (U01HL072507, R01HL087263, and R01HL090682) from the National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Publisher Copyright:
© Macmillan Publishers Limited, part of Springer Nature 2018.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Previous studies have indicated that reactive oxygen species produced by NADPH oxidase (Nox) are important risk factors of hypertension. The current study aims to examine the associations of Nox-related genes with longitudinal blood pressure (BP) changes and the risk of incident hypertension in the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) follow-up study. A total of 1,768 participants from 633 families were included in our analysis. Nine BP measurements were obtained in the morning at baseline and during two follow-up visits. The mixed-effect models were used to investigate the associations of 52 tagged single-nucleotide polymorphisms in 11 Nox-related genes with BP changes and incident hypertension. Gene-based analyses were performed by truncated product method (TPM) and Versatile Gene-based Association Study (VEGAS). Over the 7.2 years of follow-up, systolic BP (SBP) and diastolic BP (DBP) increased, and 32.1% (512) of participants developed hypertension. SNPs rs12094228, rs16861188 and rs12066019 in NCF2 were significantly associated with longitudinal change in SBP (Pinteraction = 1.1 × 10-3, 2.8 × 10-3 and 1.2 × 10-3, respectively). Gene-based analyses revealed that NCF2 was significantly associated with SBP (PTPM = 1.00 × 10-6, PVEGAS = 1.26 × 10-4) and DBP changes (PTPM = 5.84 × 10-4, PVEGAS = 1.04 × 10-3). These findings suggested that NCF2 may play an important role in BP changes over time in the Han Chinese population.
AB - Previous studies have indicated that reactive oxygen species produced by NADPH oxidase (Nox) are important risk factors of hypertension. The current study aims to examine the associations of Nox-related genes with longitudinal blood pressure (BP) changes and the risk of incident hypertension in the Genetic Epidemiology Network of Salt Sensitivity (GenSalt) follow-up study. A total of 1,768 participants from 633 families were included in our analysis. Nine BP measurements were obtained in the morning at baseline and during two follow-up visits. The mixed-effect models were used to investigate the associations of 52 tagged single-nucleotide polymorphisms in 11 Nox-related genes with BP changes and incident hypertension. Gene-based analyses were performed by truncated product method (TPM) and Versatile Gene-based Association Study (VEGAS). Over the 7.2 years of follow-up, systolic BP (SBP) and diastolic BP (DBP) increased, and 32.1% (512) of participants developed hypertension. SNPs rs12094228, rs16861188 and rs12066019 in NCF2 were significantly associated with longitudinal change in SBP (Pinteraction = 1.1 × 10-3, 2.8 × 10-3 and 1.2 × 10-3, respectively). Gene-based analyses revealed that NCF2 was significantly associated with SBP (PTPM = 1.00 × 10-6, PVEGAS = 1.26 × 10-4) and DBP changes (PTPM = 5.84 × 10-4, PVEGAS = 1.04 × 10-3). These findings suggested that NCF2 may play an important role in BP changes over time in the Han Chinese population.
UR - http://www.scopus.com/inward/record.url?scp=85042211208&partnerID=8YFLogxK
U2 - 10.1038/s41371-018-0041-6
DO - 10.1038/s41371-018-0041-6
M3 - Article
C2 - 29463833
AN - SCOPUS:85042211208
SN - 0950-9240
VL - 32
SP - 287
EP - 293
JO - Journal of Human Hypertension
JF - Journal of Human Hypertension
IS - 4
ER -