Associations of coffee and tea consumption with lung cancer risk

Jingjing Zhu; Stephanie A. Smith-Warner; Danxia Yu; Xuehong Zhang; William J. Blot; Yong Bing Xiang; Rashmi Sinha; Yikyung Park; Shoichiro Tsugane; Emily White; Woon Puay Koh; Sue K. Park; Norie Sawada; Seiki Kanemura; Yumi Sugawara; Ichiro Tsuji; Kim Robien; Yasutake Tomata; Keun Young Yoo; Jeongseon Kim; Jian Min Yuan; Yu Tang Gao; Nathaniel Rothman; De Ann Lazovich; Sarah K. Abe; Md Shafiur Rahman; Erikka Loftfield; Yumie Takata; Xin Li; Jung Eun Lee; Eiko Saito; Neal D. Freedman; Manami Inoue; Qing Lan; Walter C. Willett; Wei Zheng; Xiao Ou Shu

doi:10.1002/ijc.33445

Associations of coffee and tea consumption with lung cancer risk

Jingjing Zhu, Stephanie A. Smith-Warner, Danxia Yu, Xuehong Zhang, William J. Blot, Yong Bing Xiang, Rashmi Sinha, Yikyung Park, Shoichiro Tsugane, Emily White, Woon Puay Koh, Sue K. Park, Norie Sawada, Seiki Kanemura, Yumi Sugawara, Ichiro Tsuji, Kim Robien, Yasutake Tomata, Keun Young Yoo, Jeongseon KimJian Min Yuan, Yu Tang Gao, Nathaniel Rothman, De Ann Lazovich, Sarah K. Abe, Md Shafiur Rahman, Erikka Loftfield, Yumie Takata, Xin Li, Jung Eun Lee, Eiko Saito, Neal D. Freedman, Manami Inoue, Qing Lan, Walter C. Willett, Wei Zheng, Xiao Ou Shu

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Abstract

Associations of coffee and tea consumption with lung cancer risk have been inconsistent, and most lung cancer cases investigated were smokers. Included in this study were over 1.1 million participants from 17 prospective cohorts. Cox regression analyses were conducted to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Potential effect modifications by sex, smoking, race, cancer subtype and coffee type were assessed. After a median 8.6 years of follow-up, 20 280 incident lung cancer cases were identified. Compared with noncoffee and nontea consumption, HRs (95% CIs) associated with exclusive coffee drinkers (≥2 cups/d) among current, former and never smokers were 1.30 (1.15-1.47), 1.49 (1.27-1.74) and 1.35 (1.15-1.58), respectively. Corresponding HRs for exclusive tea drinkers (≥2 cups/d) were 1.16 (1.02-1.32), 1.10 (0.92-1.32) and 1.37 (1.17-1.61). In general, the coffee and tea associations did not differ significantly by sex, race or histologic subtype. Our findings suggest that higher consumption of coffee or tea is associated with increased lung cancer risk. However, these findings should not be assumed to be causal because of the likelihood of residual confounding by smoking, including passive smoking, and change of coffee and tea consumption after study enrolment.

Original language	English
Pages (from-to)	2457-2470
Number of pages	14
Journal	International Journal of Cancer
Volume	148
Issue number	10
DOIs	https://doi.org/10.1002/ijc.33445
State	Published - May 15 2021

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Zhu, J., Smith-Warner, S. A., Yu, D., Zhang, X., Blot, W. J., Xiang, Y. B., Sinha, R., Park, Y., Tsugane, S., White, E., Koh, W. P., Park, S. K., Sawada, N., Kanemura, S., Sugawara, Y., Tsuji, I., Robien, K., Tomata, Y., Yoo, K. Y., ... Shu, X. O. (2021). Associations of coffee and tea consumption with lung cancer risk. International Journal of Cancer, 148(10), 2457-2470. https://doi.org/10.1002/ijc.33445

@article{ebe0bf0457ca490392a888690818206c,

title = "Associations of coffee and tea consumption with lung cancer risk",

abstract = "Associations of coffee and tea consumption with lung cancer risk have been inconsistent, and most lung cancer cases investigated were smokers. Included in this study were over 1.1 million participants from 17 prospective cohorts. Cox regression analyses were conducted to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Potential effect modifications by sex, smoking, race, cancer subtype and coffee type were assessed. After a median 8.6 years of follow-up, 20 280 incident lung cancer cases were identified. Compared with noncoffee and nontea consumption, HRs (95% CIs) associated with exclusive coffee drinkers (≥2 cups/d) among current, former and never smokers were 1.30 (1.15-1.47), 1.49 (1.27-1.74) and 1.35 (1.15-1.58), respectively. Corresponding HRs for exclusive tea drinkers (≥2 cups/d) were 1.16 (1.02-1.32), 1.10 (0.92-1.32) and 1.37 (1.17-1.61). In general, the coffee and tea associations did not differ significantly by sex, race or histologic subtype. Our findings suggest that higher consumption of coffee or tea is associated with increased lung cancer risk. However, these findings should not be assumed to be causal because of the likelihood of residual confounding by smoking, including passive smoking, and change of coffee and tea consumption after study enrolment.",

author = "Jingjing Zhu and Smith-Warner, {Stephanie A.} and Danxia Yu and Xuehong Zhang and Blot, {William J.} and Xiang, {Yong Bing} and Rashmi Sinha and Yikyung Park and Shoichiro Tsugane and Emily White and Koh, {Woon Puay} and Park, {Sue K.} and Norie Sawada and Seiki Kanemura and Yumi Sugawara and Ichiro Tsuji and Kim Robien and Yasutake Tomata and Yoo, {Keun Young} and Jeongseon Kim and Yuan, {Jian Min} and Gao, {Yu Tang} and Nathaniel Rothman and Lazovich, {De Ann} and Abe, {Sarah K.} and Rahman, {Md Shafiur} and Erikka Loftfield and Yumie Takata and Xin Li and Lee, {Jung Eun} and Eiko Saito and Freedman, {Neal D.} and Manami Inoue and Qing Lan and Willett, {Walter C.} and Wei Zheng and Shu, {Xiao Ou}",

note = "Publisher Copyright: {\textcopyright} 2020 UICC",

year = "2021",

month = may,

day = "15",

doi = "10.1002/ijc.33445",

language = "English",

volume = "148",

pages = "2457--2470",

journal = "International Journal of Cancer",

issn = "0020-7136",

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Zhu, J, Smith-Warner, SA, Yu, D, Zhang, X, Blot, WJ, Xiang, YB, Sinha, R, Park, Y, Tsugane, S, White, E, Koh, WP, Park, SK, Sawada, N, Kanemura, S, Sugawara, Y, Tsuji, I, Robien, K, Tomata, Y, Yoo, KY, Kim, J, Yuan, JM, Gao, YT, Rothman, N, Lazovich, DA, Abe, SK, Rahman, MS, Loftfield, E, Takata, Y, Li, X, Lee, JE, Saito, E, Freedman, ND, Inoue, M, Lan, Q, Willett, WC, Zheng, W & Shu, XO 2021, 'Associations of coffee and tea consumption with lung cancer risk', International Journal of Cancer, vol. 148, no. 10, pp. 2457-2470. https://doi.org/10.1002/ijc.33445

TY - JOUR

T1 - Associations of coffee and tea consumption with lung cancer risk

AU - Zhu, Jingjing

AU - Smith-Warner, Stephanie A.

AU - Yu, Danxia

AU - Zhang, Xuehong

AU - Blot, William J.

AU - Xiang, Yong Bing

AU - Sinha, Rashmi

AU - Park, Yikyung

AU - Tsugane, Shoichiro

AU - White, Emily

AU - Koh, Woon Puay

AU - Park, Sue K.

AU - Sawada, Norie

AU - Kanemura, Seiki

AU - Sugawara, Yumi

AU - Tsuji, Ichiro

AU - Robien, Kim

AU - Tomata, Yasutake

AU - Yoo, Keun Young

AU - Kim, Jeongseon

AU - Yuan, Jian Min

AU - Gao, Yu Tang

AU - Rothman, Nathaniel

AU - Lazovich, De Ann

AU - Abe, Sarah K.

AU - Rahman, Md Shafiur

AU - Loftfield, Erikka

AU - Takata, Yumie

AU - Li, Xin

AU - Lee, Jung Eun

AU - Saito, Eiko

AU - Freedman, Neal D.

AU - Inoue, Manami

AU - Lan, Qing

AU - Willett, Walter C.

AU - Zheng, Wei

AU - Shu, Xiao Ou

PY - 2021/5/15

Y1 - 2021/5/15

N2 - Associations of coffee and tea consumption with lung cancer risk have been inconsistent, and most lung cancer cases investigated were smokers. Included in this study were over 1.1 million participants from 17 prospective cohorts. Cox regression analyses were conducted to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Potential effect modifications by sex, smoking, race, cancer subtype and coffee type were assessed. After a median 8.6 years of follow-up, 20 280 incident lung cancer cases were identified. Compared with noncoffee and nontea consumption, HRs (95% CIs) associated with exclusive coffee drinkers (≥2 cups/d) among current, former and never smokers were 1.30 (1.15-1.47), 1.49 (1.27-1.74) and 1.35 (1.15-1.58), respectively. Corresponding HRs for exclusive tea drinkers (≥2 cups/d) were 1.16 (1.02-1.32), 1.10 (0.92-1.32) and 1.37 (1.17-1.61). In general, the coffee and tea associations did not differ significantly by sex, race or histologic subtype. Our findings suggest that higher consumption of coffee or tea is associated with increased lung cancer risk. However, these findings should not be assumed to be causal because of the likelihood of residual confounding by smoking, including passive smoking, and change of coffee and tea consumption after study enrolment.

AB - Associations of coffee and tea consumption with lung cancer risk have been inconsistent, and most lung cancer cases investigated were smokers. Included in this study were over 1.1 million participants from 17 prospective cohorts. Cox regression analyses were conducted to estimate hazard ratios (HRs) and 95% confidence intervals (CIs). Potential effect modifications by sex, smoking, race, cancer subtype and coffee type were assessed. After a median 8.6 years of follow-up, 20 280 incident lung cancer cases were identified. Compared with noncoffee and nontea consumption, HRs (95% CIs) associated with exclusive coffee drinkers (≥2 cups/d) among current, former and never smokers were 1.30 (1.15-1.47), 1.49 (1.27-1.74) and 1.35 (1.15-1.58), respectively. Corresponding HRs for exclusive tea drinkers (≥2 cups/d) were 1.16 (1.02-1.32), 1.10 (0.92-1.32) and 1.37 (1.17-1.61). In general, the coffee and tea associations did not differ significantly by sex, race or histologic subtype. Our findings suggest that higher consumption of coffee or tea is associated with increased lung cancer risk. However, these findings should not be assumed to be causal because of the likelihood of residual confounding by smoking, including passive smoking, and change of coffee and tea consumption after study enrolment.

UR - http://www.scopus.com/inward/record.url?scp=85098149199&partnerID=8YFLogxK

U2 - 10.1002/ijc.33445

DO - 10.1002/ijc.33445

M3 - Article

C2 - 33326609

AN - SCOPUS:85098149199

SN - 0020-7136

VL - 148

SP - 2457

EP - 2470

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 10

ER -

Associations of coffee and tea consumption with lung cancer risk

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