Associations of aspirin and other anti-inflammatory medications with mammographic breast density and breast cancer risk

Lusine Yaghjyan, Akemi Wijayabahu, A. Heather Eliassen, Graham Colditz, Bernard Rosner, Rulla M. Tamimi

Research output: Contribution to journalArticlepeer-review

Abstract

Purpose: We investigated the associations of aspirin and other non-steroid anti-inflammatory drugs with mammographic breast density (MBD) and their interactions in relation to breast cancer risk. Methods: This study included 3,675 cancer-free women within the Nurses’ Health Study (NHS) and Nurses’ Health Study II (NHSII) cohorts. Percent breast density (PD), absolute dense area (DA), and non-dense area (NDA) were measured from digitized film mammograms using a computer-assisted thresholding technique; all measures were square root-transformed. Information on medication use was collected in 1980 (NHS) and 1989 (NHSII) and updated biennially. Medication use was defined as none, past or current; average cumulative dose and frequency were calculated for all past or current users from all bi-annual questionnaires preceding the mammogram date. We used generalized linear regression to quantify associations of medications with MBD. Two-way interactions were examined in logistic regression models. Results: In multivariate analysis, none of the anti-inflammatory medications were associated with PD, DA, and NDA. We found no interactions of any of the medications with PD with respect to breast cancer risk (all p-interactions > 0.05). However, some of the aspirin variables appeared to have positive associations with breast cancer risk limited only to women with PD 10–24% (past aspirin OR 1.56, 95% CI 1.03–2.35; current aspirin with < 5 years of use OR 1.82, 95% CI 1.01–3.28; current aspirin with ≥ 5 years of use OR 1.89, 95% CI 1.26–2.82). Conclusions: Aspirin and NSAIDs are not associated with breast density measures. We found no interactions of aspirin with MBD in relation to breast cancer risk.

Original languageEnglish
JournalCancer Causes and Control
DOIs
StateAccepted/In press - Jan 1 2020

Keywords

  • Aspirin
  • Breast cancer
  • Breast density
  • Interactions

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