TY - JOUR
T1 - Associations between unprocessed red and processed meat, poultry, seafood and egg intake and the risk of prostate cancer
T2 - A pooled analysis of 15 prospective cohort studies
AU - Wu, Kana
AU - Spiegelman, Donna
AU - Hou, Tao
AU - Albanes, Demetrius
AU - Allen, Naomi E.
AU - Berndt, Sonja I.
AU - Van Den Brandt, Piet A.
AU - Giles, Graham G.
AU - Giovannucci, Edward
AU - Alexandra Goldbohm, R.
AU - Goodman, Gary G.
AU - Goodman, Phyllis J.
AU - Håkansson, Niclas
AU - Inoue, Manami
AU - Key, Timothy J.
AU - Kolonel, Laurence N.
AU - Männistö, Satu
AU - McCullough, Marjorie L.
AU - Neuhouser, Marian L.
AU - Park, Yikyung
AU - Platz, Elizabeth A.
AU - Schenk, Jeannette M.
AU - Sinha, Rashmi
AU - Stampfer, Meir J.
AU - Stevens, Victoria L.
AU - Tsugane, Shoichiro
AU - Visvanathan, Kala
AU - Wilkens, Lynne R.
AU - Wolk, Alicja
AU - Ziegler, Regina G.
AU - Smith-Warner, Stephanie A.
N1 - Publisher Copyright:
© 2015 UICC.
PY - 2016/5/15
Y1 - 2016/5/15
N2 - Reports relating meat intake to prostate cancer risk are inconsistent. Associations between these dietary factors and prostate cancer were examined in a consortium of 15 cohort studies. During follow-up, 52,683 incident prostate cancer cases, including 4,924 advanced cases, were identified among 842,149 men. Cox proportional hazard models were used to calculate study-specific relative risks (RR) and then pooled using random effects models. Results do not support a substantial effect of total red, unprocessed red and processed meat for all prostate cancer outcomes, except for a modest positive association for tumors identified as advanced stage at diagnosis (advanced(r)). For seafood, no substantial effect was observed for prostate cancer regardless of stage or grade. Poultry intake was inversely associated with risk of advanced and fatal cancers (pooled multivariable RR [MVRR], 95% confidence interval, comparing ≥45 vs. <5 g/day: advanced 0.83, 0.70-0.99; trend test p value 0.29), fatal, 0.69, 0.59-0.82, trend test p value 0.16). Participants who ate ≥25 versus <5 g/day of eggs (1 egg 50 g) had a significant 14% increased risk of advanced and fatal cancers (advanced 1.14, 1.01-1.28, trend test p value 0.01; fatal 1.14, 1.00-1.30, trend test p value 0.01). When associations were analyzed separately by geographical region (North America vs. other continents), positive associations between unprocessed red meat and egg intake, and inverse associations between poultry intake and advanced, advanced(r) and fatal cancers were limited to North American studies. However, differences were only statistically significant for eggs. Observed differences in associations by geographical region warrant further investigation.
AB - Reports relating meat intake to prostate cancer risk are inconsistent. Associations between these dietary factors and prostate cancer were examined in a consortium of 15 cohort studies. During follow-up, 52,683 incident prostate cancer cases, including 4,924 advanced cases, were identified among 842,149 men. Cox proportional hazard models were used to calculate study-specific relative risks (RR) and then pooled using random effects models. Results do not support a substantial effect of total red, unprocessed red and processed meat for all prostate cancer outcomes, except for a modest positive association for tumors identified as advanced stage at diagnosis (advanced(r)). For seafood, no substantial effect was observed for prostate cancer regardless of stage or grade. Poultry intake was inversely associated with risk of advanced and fatal cancers (pooled multivariable RR [MVRR], 95% confidence interval, comparing ≥45 vs. <5 g/day: advanced 0.83, 0.70-0.99; trend test p value 0.29), fatal, 0.69, 0.59-0.82, trend test p value 0.16). Participants who ate ≥25 versus <5 g/day of eggs (1 egg 50 g) had a significant 14% increased risk of advanced and fatal cancers (advanced 1.14, 1.01-1.28, trend test p value 0.01; fatal 1.14, 1.00-1.30, trend test p value 0.01). When associations were analyzed separately by geographical region (North America vs. other continents), positive associations between unprocessed red meat and egg intake, and inverse associations between poultry intake and advanced, advanced(r) and fatal cancers were limited to North American studies. However, differences were only statistically significant for eggs. Observed differences in associations by geographical region warrant further investigation.
KW - diet
KW - egg
KW - poultry
KW - processed meat
KW - prostate cancer
KW - seafood
KW - unprocessed red meat
UR - http://www.scopus.com/inward/record.url?scp=84960093619&partnerID=8YFLogxK
U2 - 10.1002/ijc.29973
DO - 10.1002/ijc.29973
M3 - Article
C2 - 26685908
AN - SCOPUS:84960093619
SN - 0020-7136
VL - 138
SP - 2368
EP - 2382
JO - International Journal of Cancer
JF - International Journal of Cancer
IS - 10
ER -