Associations between dimensional personality measures and preclinical atherosclerosis: The cardiovascular risk in Young Finns study

Tom Rosenström, Markus Jokela, Claude Robert Cloninger, Mirka Hintsanen, Markus Juonala, Olli Raitakari, Jorma Viikari, Liisa Keltikangas-Järvinen

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    22 Scopus citations


    Objective: To assess how multidimensional personality-trait theories, such as the Psychobiological Model of Temperament and Character, and the Five-factor Model of Personality, are associated with subclinical atherosclerosis as indicated by carotid intima-media thickness (IMT). The analysis was designed to tolerate non-linear development in which the same personality profiles can have multiple final outcomes and different antecedent profiles can have the same final outcome. Methods: 605 men and 844 women (average age 31.6year, s.d.=5.0, range=24-39) provided data on IMT and traits of the psychobiological model, 725 men and 1011 women were assessed for IMT and the five-factor model (age 37.7year, s.d.=5.0, range=30-45). Robust multidimensional Hotelling's T 2 statistic was used to detect personality differences between participants with high IMT and others. Model-based clustering method further explored the effect. Results: Those with a high level of subclinical atherosclerosis within the sample (highest IMT-decile) had a combined higher persistence (i.e., were perseverative or perfectionistic), more disorganized (schizotypal) character, and more antisocial temperamental configuration than others (P= 0.019). No effect was found for the five-factor model (P= 0.978). Traditional methods that did not account for multidimensionality and nonlinearity did not detect an association. Conclusion: Psychological well-being may have positive effects on health that reduce atherosclerosis in the population as a whole. Increased subclinical atherosclerosis was associated with a profile that combines known risk factors, such as cynical distrust and hostile tendencies. More frequent use of statistical procedures that can cope with non-linear interactions in complex psychobiological systems may facilitate scientific advances in health promotion.

    Original languageEnglish
    Pages (from-to)336-343
    Number of pages8
    JournalJournal of Psychosomatic Research
    Issue number5
    StatePublished - May 2012


    • Atherosclerosis
    • Behavioral medicine
    • Carotid intima-media thickness
    • Multivariate analysis
    • Personality
    • Temperament and character


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