Associations between Atrial Arrhythmias and Brain Amyloid Deposition: The ARIC-PET Study

Michelle C. Johansen; Wendy Wang; Michael J. Zhang; Alvaro Alonso; Dean F. Wong; Rebecca F. Gottesman; Lin Y. Chen

doi:10.3233/JAD-215378

Associations between Atrial Arrhythmias and Brain Amyloid Deposition: The ARIC-PET Study

Michelle C. Johansen, Wendy Wang, Michael J. Zhang, Alvaro Alonso, Dean F. Wong, Rebecca F. Gottesman, Lin Y. Chen

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The aim of this study is to determine if there is an association between atrial arrhythmias and brain amyloid-β (Aβ), measured on florbetapir (FBP) PET. 346 nondemented participants from the Atherosclerosis Risk in Communities study underwent FBP-PET, 185 also wore Zio® XT Patch. The associations between global cortical Aβ (>1.2 standardized uptake value ratio) and history of atrial fibrillation, zio-defined atrial tachycardia and premature atrial contractions, each, were evaluated. Among nondemented community-dwelling older adults, we did not find an association between atrial arrhythmias and Aβ. Other brain pathology may underlie the association described between atrial arrhythmias and cognition.

Original language	English
Pages (from-to)	43-48
Number of pages	6
Journal	Journal of Alzheimer's Disease
Volume	86
Issue number	1
DOIs	https://doi.org/10.3233/JAD-215378
State	Published - 2022

Keywords

Arrhythmias
atrial fibrillation
cognitive impairment
imaging

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10.3233/JAD-215378

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abstract = "The aim of this study is to determine if there is an association between atrial arrhythmias and brain amyloid-β (Aβ), measured on florbetapir (FBP) PET. 346 nondemented participants from the Atherosclerosis Risk in Communities study underwent FBP-PET, 185 also wore Zio{\textregistered} XT Patch. The associations between global cortical Aβ (>1.2 standardized uptake value ratio) and history of atrial fibrillation, zio-defined atrial tachycardia and premature atrial contractions, each, were evaluated. Among nondemented community-dwelling older adults, we did not find an association between atrial arrhythmias and Aβ. Other brain pathology may underlie the association described between atrial arrhythmias and cognition.",

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AU - Wong, Dean F.

AU - Gottesman, Rebecca F.

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AB - The aim of this study is to determine if there is an association between atrial arrhythmias and brain amyloid-β (Aβ), measured on florbetapir (FBP) PET. 346 nondemented participants from the Atherosclerosis Risk in Communities study underwent FBP-PET, 185 also wore Zio® XT Patch. The associations between global cortical Aβ (>1.2 standardized uptake value ratio) and history of atrial fibrillation, zio-defined atrial tachycardia and premature atrial contractions, each, were evaluated. Among nondemented community-dwelling older adults, we did not find an association between atrial arrhythmias and Aβ. Other brain pathology may underlie the association described between atrial arrhythmias and cognition.

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Associations between Atrial Arrhythmias and Brain Amyloid Deposition: The ARIC-PET Study

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